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Articles Published Processes
2/1/2016 9:28:00 AM | Browse: 1284 | Download: 2369
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Received |
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2015-06-14 17:44 |
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Peer-Review Started |
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2015-06-15 13:27 |
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To Make the First Decision |
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2015-10-14 17:30 |
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Return for Revision |
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2015-10-20 09:44 |
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Revised |
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2015-10-28 14:30 |
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Second Decision |
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2015-11-09 08:09 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-01 09:12 |
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Articles in Press |
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2015-12-01 09:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-21 15:00 |
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Publish the Manuscript Online |
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2016-01-31 11:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuli Christine Chang, Jan-Gowth Chang, Ta-Chih Liu, Chien-Yu Lin, Shu-Fen Yang, Cheng-Mao Ho, William Tzu-Liang Chen and Ya-Sian Chang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Medical University Hospital |
DMR-103-017 |
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| Corresponding Author |
Ya-Sian Chang, PhD, Epigenome Research Center, China Medical University Hospital, 2 Yuh-Der Road, Taichung 40447, Taiwan. t25074@mail.cmuh.org.tw |
| Key Words |
Colorectal cancer; Driver gene; Colorectal cancer-related pathway; Mutation; High-resolution melting analysis |
| Core Tip |
In Taiwan, colorectal cancer (CRC) has had the highest incidences among cancers recently. In a study of 103 patients with CRC, we identified 18 novel mutations in APC, MLH1, MSH2, PMS2, SMAD4 and TP53. We assessed the frequency of non-pathological somatic mutations during oncogenesis, which has not been explored before. Our results indicated 16 de novo mutations that have been previously described in a public database and were detected in cancerous tissues only, but not in the patient’s blood cells. We suggest these mutation sites may belong to a frequent mutational hotspot in both germline and cancerous tissues.
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| Publish Date |
2016-01-31 11:48 |
| Citation |
Chang YC, Chang JG, Liu TC, Lin CY, Yang SF, Ho CM, Chen WT, Chang YS. Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients. World J Gastroenterol 2016; 22(7): 2314-2325 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i7/2314.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i7.2314 |
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