Publication Name	World Journal of Gastroenterology
Manuscript ID	20644
Country	China

Received	2015-06-15 08:48
Peer-Review Started	2015-06-16 09:30
To Make the First Decision	2015-07-19 17:14
Return for Revision	2015-07-27 11:26
Revised	2015-08-09 15:16
Second Decision	2015-09-23 19:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 08:54
Articles in Press	2015-09-30 08:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-10-15 07:11
Typeset the Manuscript	2015-12-10 18:19
Publish the Manuscript Online	2015-12-24 11:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Gong, Hui Dong, Shu-Jun Jiang, Ding-Kun Wang, Ke Fang, De-Sen Yang, Xin Zou, Li-Jun Xu, Kai-Fu Wang and Fu-Er Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81273683 National Natural Science Foundation of China 81473637
Corresponding Author	Dr. Fu-Er Lu, Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1037 Jiefang Road, Wuhan 430030, Hubei Province, China. felu@tjh.tjmu.edu.cn
Key Words	Fenugreek lactone; Diabetes; Oxidative stress; Insulin secretion; Apoptosis
Core Tip	Fenugreek is a widely used traditional Chinese medicine that can improve hyperglycemia. The hypoglycemic active ingredients and mechanisms of fenugreek remain unclear. We studied an ingredient of fenugreek, fenugreek lactone, and our results suggest that fenugreek lactone attenuates palmitate-induced apoptosis and insulin secretion dysfunction in NIT-1 pancreatic β-cells by improving oxidative stress.
Publish Date	2015-12-24 11:11
Citation	Gong J, Dong H, Jiang SJ, Wang DK, Fang K, Yang DS, Zou X, Xu LJ, Wang KF, Lu FE. Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells. World J Gastroenterol 2015; 21(48): 13457-13465
URL	http://www.wjgnet.com/1007-9327/full/v21/i48/13457.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i48.13457

Full Article (PDF)	WJG-21-13457.pdf
Full Article (Word)	WJG-21-13457.doc
Manuscript File	20644-Review.docx
Answering Reviewers	20644-Answering reviewers.pdf
Audio Core Tip	20644-Audio core tip.mp3
Biostatistics Review Certificate	20644-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20644-Conflict-of-interest statement.pdf
Copyright License Agreement	20644-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	20644-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	20644-Language certificate.pdf
Peer-review Report	20644-Peer-review(s).pdf
Scientific Misconduct Check	20644-Scientific misconduct check.pdf
Scientific Editor Work List	20644-Scientific editor work list.pdf