Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	20671
Country	India

Received	2015-06-16 09:42
Peer-Review Started	2015-06-17 14:08
To Make the First Decision	2015-07-27 18:36
Return for Revision	2015-07-31 18:43
Revised	2015-08-07 15:07
Second Decision	2015-10-13 09:01
Accepted by Journal Editor-in-Chief	2015-10-14 02:41
Accepted by Executive Editor-in-Chief	2015-10-27 18:01
Articles in Press	2015-10-27 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-03 19:27
Publish the Manuscript Online	2015-12-14 21:02

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: Current status and challenges
Manuscript Source	Invited Manuscript
All Author List	Anil Suri, Nirmala Jagadish, Shikha Saini and Namita Gupta
Funding Agency and Grant Number	Funding Agency Grant Number Indo-UK Cancer Research Program BT/IN/UK/NII/2006 Centre for Molecular Medicine BT/PR/14549/MED/14/1291 NII-core funding, Department of Biotechnology, Government of India
Corresponding Author	Dr. Anil Suri, FNASc, FAMS, Cancer Microarray, Genes and Proteins Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. anil@nii.res.in
Key Words	Cancer testis antigens; Colorectal cancer; Testis specific genes; Biomarkers; Immunotherapy
Core Tip	Despite of the availability of enormous tumor antigens, there is a dearth of targets for biomarkers and immunotherapy for clinical cancer management. Cost-effectiveness and invasiveness associated with colonoscopy hinders its implications in less developed and developing countries. Colorectal cancer treatment including surgery and radiation has significant side effects on normal tissues. Recently a new category of antigens has been discovered which are expressed in tumor cells but not in normal tissues except the immuno-privileged testis. Targeting such antigens would be specific to the cancer cells with no deleterious effects on normal cells. Scope of these magic bullets in colorectal cancer is discussed in this review.
Publish Date	2015-12-14 21:02
Citation	Suri A, Jagadish N, Saini S, Gupta N. Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: Current status and challenges. World J Gastrointest Oncol 2015; 7(12): 492-502
URL	http://www.wjgnet.com/1948-5204/full/v7/i12/492.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i12.492

Full Article (PDF)	WJGO-7-492.pdf
Full Article (Word)	WJGO-7-492.doc
Manuscript File	20671-Review.docx
Answering Reviewers	20671-Answering reviewers.pdf
Audio Core Tip	20671-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20671-Conflict-of-interest statement.pdf
Copyright License Agreement	20671-Copyright assignment.pdf
Peer-review Report	20671-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20671-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20671-Scientific misconduct check.pdf
Scientific Editor Work List	20671-Scientific editor work list.pdf