Publication Name	World Journal of Gastroenterology
Manuscript ID	20706
Country	Japan

Received	2015-06-17 08:40
Peer-Review Started	2015-06-19 10:45
To Make the First Decision	2015-07-20 13:52
Return for Revision	2015-07-28 11:30
Revised	2015-08-06 14:05
Second Decision	2015-09-23 19:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 08:56
Articles in Press	2015-09-30 08:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-19 20:44
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Gut microbiota and host metabolism in liver cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Makoto Usami, Makoto Miyoshi and Hayato Yamashita
Funding Agency and Grant Number
Corresponding Author	Makoto Usami, MD, PhD, Division of Nutrition and Metabolism, Department of Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan. musa@kobe-u.ac.jp
Key Words	Liver cirrhosis; Microbiota; Metabolism; Fatty acids; Probiotics
Core Tip	The gut microbiota has the capacity to produce a diverse range of compounds that have a major role in regulating the activity of distal organs and the liver is strategically positioned downstream of the gut indicating the importance of the gut-liver axis. This review focuses on gut microbiota and host metabolism in liver cirrhosis. The serum lipid levels of phospholipids, free fatty acids, eicosapentaenoic acid, arachidonic acid, and docosahexaenoic acid have significant correlations with specific fecal flora in liver cirrhosis. Various blood metabolome such as cytokines, amino acids, and vitamins are correlated with gut microbiota in probiotics-treated liver cirrhosis patients.
Publish Date	2015-11-03 17:31
Citation	Usami M, Miyoshi M, Yamashita H. Gut microbiota and host metabolism in liver cirrhosis. World J Gastroenterol 2015; 21(41): 11597-11608
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11597.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11597

Full Article (PDF)	WJG-21-11597.pdf
Full Article (Word)	WJG-21-11597.doc
Manuscript File	20706-Review.docx
Answering Reviewers	20706-Answering reviewers.pdf
Audio Core Tip	20706-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20706-Conflict-of interest statement.pdf
Copyright License Agreement	20706-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	20706-Language certificate.pdf
Peer-review Report	20706-Peer-review(s).pdf
Scientific Misconduct Check	20706-Scientific misconduct check.pdf
Scientific Editor Work List	20706-Scientific editor work list.pdf