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Articles Published Processes
3/7/2016 11:32:00 AM | Browse: 848 | Download: 1446
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Received |
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2015-06-17 09:29 |
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Peer-Review Started |
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2015-06-19 10:53 |
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To Make the First Decision |
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2015-10-21 08:59 |
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Return for Revision |
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2015-11-14 12:31 |
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Revised |
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2015-11-14 19:32 |
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Second Decision |
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2016-01-12 16:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-01-22 16:27 |
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Articles in Press |
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2016-01-22 16:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-02-15 18:28 |
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Typeset the Manuscript |
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2016-02-26 09:35 |
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Publish the Manuscript Online |
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2016-03-07 11:32 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was
selected by an in-house editor and fully peer-reviewed by external
reviewers. It is distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license,
which permits others to distribute, remix, adapt, build upon this
work non-commercially, and license their derivative works on
different terms, provided the original work is properly cited and
the use is non-commercial. See: http://creativecommons.org/
licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing
Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Expression of p-STAT3 and vascular endothelial growthfactor in MNNG-induced precancerous lesions and gastrictumors in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Yan Wang, Lou-Lei Wang, Xuan Zheng, Li-Na Meng, Bin Lyu and Hai-Feng Jin |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hai-Feng Jin, MD, Resident Physician
of Gastroenterology, the First Affiliated Hospital of Zhejiang
Chinese Medicine University, Youdian Rd. 54, Hangzhou
310006, Zhejiang Province, China. jinhaifeng0908@163.com |
| Key Words |
Wistar rat; Precancerous gastric lesions; Gastric tumor; Vascular endothelial growth factor; p-signal
transducer and activator of transcription 3; N-methyl-N’-
nitro-N-nitrosoguanidine |
| Core Tip |
The results show that signal transducer and
activator of transcription 3 (STAT3) is partially responsible
for the progression from chronic gastritis to gastric
carcinoma induced by N-methyl-N’-nitro-N-nitrosoguanidine
(MNNG) and is significantly related to the expression of
vascular endothelial growth factor (VEGF) during this
process. It is considered that STAT3 induces an abnormal
level of VEGF expression
to promote the formation of
gastric carcinoma. To the best of our knowledge, this is the
first report to show that p-STAT3 is persistently
activated
during the progression of chronic gastritis to gastritis
carcinoma induced by the administration of MNNG in rats,
and was positively associated with the expression of VEGF. |
| Publish Date |
2016-03-07 11:32 |
| Citation |
Wang XY, Wang LL, Zheng X, Meng LN, Lyu B, Jin HF.
Expression of p-STAT3 and vascular endothelial growth factor in
MNNG-induced precancerous lesions and gastric tumors in rats.
World J Gastrointest Oncol 2016; 8(3): 305-313 |
| URL |
http://www.wjgnet. com/1948-5204/full/v8/i3/305.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v8.i3.305 |
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