Publication Name	World Journal of Gastroenterology
Manuscript ID	20713
Country	Japan

Received	2015-06-17 08:20
Peer-Review Started	2015-06-19 11:03
To Make the First Decision	2015-07-19 17:15
Return for Revision	2015-07-27 11:28
Revised	2015-08-07 14:36
Second Decision	2015-09-12 22:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-14 11:38
Articles in Press	2015-09-14 11:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-28 12:12
Publish the Manuscript Online	2015-11-18 12:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects
Manuscript Source	Unsolicited Manuscript
All Author List	Masahiro Kikuchi, Yusuke Ushida, Hirokazu Shiozawa, Rumiko Umeda, Kota Tsuruya, Yudai Aoki, Hiroyuki Suganuma and Yasuhiro Nishizaki
Funding Agency and Grant Number
Corresponding Author	Yasuhiro Nishizaki, MD, PhD, Professor, Department of Clinical Health Science, Tokai University Tokyo Hospital, 1-2-5, Yoyogi, Shibuya-ku, Tokyo 153-0065, Japan. dr-yasu@jcom.home.ne.jp
Key Words	Sulforaphane; Glucoraphanin; Broccoli sprout; Nrf2; Hepatic abnormality; Oxidative stress; Phase 2 enzymes
Core Tip	A randomized, placebo-controlled, double blind trial was conducted to assess the efficacy of dietary supplementation with broccoli sprout extract containing glucoraphanin (GR), a sulforaphane (SF) precursor, on hepatic abnormalities in Japanese men without changing their lifestyle or habits. Suppl-ementation for 2 mo significantly decreased serum levels of liver function markers such as alanine amino-transferase and γ-glutamyl transpeptidase. The effect was associated with a reduction of urinary 8-hydro-xydeoxyguanosine, an oxidative stress marker. Dietary supplementation with SF precursor GR is effective in improving liver function, and represents a potent method for maintaining good liver condition.
Publish Date	2015-11-18 12:39
Citation	Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, Aoki Y, Suganuma H, Nishizaki Y. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol 2015; 21(43): 12457-12467
URL	http://www.wjgnet.com/1007-9327/full/v21/i43/12457.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i43.12457

Full Article (PDF)	WJG-21-12457.pdf
Full Article (Word)	WJG-21-12457.doc
Manuscript File	20713-Review.docx
Answering Reviewers	20713-Ansewring reviewers.pdf
Audio Core Tip	20713-Audio core tip.mp3
Biostatistics Review Certificate	20713-Biostatistics statement.pdf
Clinical Trial Registration Statement	20713-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	20713-Conflict-of-interest statement.pdf
Copyright License Agreement	20713-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	20713-Clinical trial registration statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	20713-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	20713-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	20713-Language certificate.pdf
Peer-review Report	20713-Peer-review(s).pdf
Scientific Misconduct Check	20713-Scientific misconduct check.pdf
Scientific Editor Work List	20713-Scientific editor work list.pdf