Publication Name	World Journal of Stem Cells
Manuscript ID	20720
Country	Japan

Received	2015-06-18 08:52
Peer-Review Started	2015-06-20 15:19
To Make the First Decision	2015-08-14 15:22
Return for Revision	2015-08-22 18:26
Revised	2015-09-17 21:49
Second Decision	2016-01-28 17:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-02-16 08:49
Articles in Press	2016-02-16 08:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-29 11:32
Publish the Manuscript Online	2016-04-13 13:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases
Manuscript Source	Invited Manuscript
All Author List	Chie Sugimoto, Hiroyoshi Fujita and Hiroshi Wakao
Funding Agency and Grant Number
Corresponding Author	Hiroshi Wakao, PhD, Department of Hygiene and Cellular Preventive Medicine, Graduate School of Medicine, Hokkaido University, N15W7 Kita-ku, Sapporo 060-8638, Japan. hwakao@med.hokudai.ac.jp
Key Words	Mucosal-associated invariant T cells; Induced pluripotent stem cells; Differentiation; Adoptive transfer; Inflammatory diseases; Autoimmune diseases; Disease modeling; Infectious diseases; Immunocompromised mouse
Core Tip	Mucosal-associated invariant T (MAIT) cells, a novel innate-like T cell subset abundant in humans, play a pivotal role in immune-dysregulated diseases. However, MAIT cells are quite rare in laboratory mice and show poor proliferation in vitro. This makes it difficult to delineate their physiological functions in health and disease. Therefore, we developed a method to generate human MAIT cells from induced pluripotent stem cells [redifferentiation of MAIT (reMAIT) cells]. Given that reMAIT cells harbor characteristics quasi-identical to those found in MAIT cells from human peripheral blood, they will be useful to model human diseases in animals.
Publish Date	2016-04-13 13:33
Citation	Sugimoto C, Fujita H, Wakao H. Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases. World J Stem Cells 2016; 8(4): 158-169
URL	http://www.wjgnet.com/1948-0210/full/v8/i4/158.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i4.158

Full Article (PDF)	WJSC-8-158.pdf
Full Article (Word)	WJSC-8-158.doc
Manuscript File	20720-Review.docx
Answering Reviewers	20720-Answering reviewers.pdf
Audio Core Tip	20720-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20720-Conflict-of-interest statement.pdf
Copyright License Agreement	20720-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20720-Language certificate.pdf
Peer-review Report	20720-Peer-review(s).pdf
Scientific Misconduct Check	20720-Scientific misconduct check.pdf
Scientific Editor Work List	20720-Scientific editor work list.pdf