Publication Name	World Journal of Gastroenterology
Manuscript ID	20727
Country	United Kingdom

Received	2015-06-18 08:39
Peer-Review Started	2015-06-21 19:15
To Make the First Decision	2015-08-26 09:52
Return for Revision	2015-09-01 18:11
Revised	2015-09-19 05:35
Second Decision	2015-12-08 13:52
Accepted by Journal Editor-in-Chief	2015-12-08 23:37
Accepted by Company Editor-in-Chief	2015-12-21 13:54
Articles in Press	2015-12-21 13:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-12 10:41
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira and Hafid Omar Al-Hassi
Funding Agency and Grant Number	Funding Agency Grant Number Association for International Cancer Research 120234 BBSRC Strategic Research Grant WMNIP33458 (to English N and Knight SC)
Corresponding Author	Paul J Ciclitira, Professor, Department of Gastroenterology, The Rayne Institute, St Thomas’ Hospital, 4th Floor Lambeth Wing, London SE1 7EH, United Kingdom. paul.ciclitira@kcl.ac.uk
Key Words	Claudin; Tight junction; Ulcerative colitis; Pouchitis; Crohn’s disease
Core Tip	Epithelial barrier function is compromised in inflammatory bowel diseases (IBD). Apical tight junction proteins, in particular claudins, are key players in epithelial barrier function. However, there is little consensus regarding the expression of most claudin isoforms in these conditions or whether these findings are primary or secondary to disease pathogenesis. Knowledge of tight junction protein expression and function in IBD and IBD associated colorectal cancer will enhance our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities.
Publish Date	2016-03-14 08:44
Citation	Landy J, Ronde E, English N, Clark SK, Hart AL, Knight SC, Ciclitira PJ, Al-Hassi HO. Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. World J Gastroenterol 2016; 22(11): 3117-3126
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3117.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3117

Full Article (PDF)	WJG-22-3117.pdf
Full Article (Word)	WJG-22-3117.doc
Manuscript File	20727-Review.docx
Answering Reviewers	20727-Answering reviewers.pdf
Audio Core Tip	20727-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20727-Conflict-of-interest statement.pdf
Copyright License Agreement	20727-Copyright assignment.pdf
Peer-review Report	20727-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20727-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20727-Scientific misconduct check.pdf
Scientific Editor Work List	20727-Scientific editor work list.pdf