Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	20751
Country	Australia

Received	2015-06-20 14:08
Peer-Review Started	2015-06-21 14:07
To Make the First Decision	2015-08-14 15:22
Return for Revision	2015-08-24 15:30
Revised	2015-09-03 23:15
Second Decision	2015-10-13 09:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-27 18:07
Articles in Press	2015-10-27 18:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-03 19:28
Publish the Manuscript Online	2015-12-14 21:02

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Minireviews
Article Title	Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy
Manuscript Source	Invited Manuscript
All Author List	Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich and Romana Illig
Funding Agency and Grant Number
Corresponding Author	Dr. Daniel Neureiter, MA, Associate Professor, Institute of Pathology, Paracelsus Medical University, Salzburger Landeskliniken (SALK), Müllner Haupstrasse 48, 5020 Salzburg, Austria. d.neureiter@salk.at
Key Words	Pancreatitis; Pancreatic cancer; Epigenetics; Histone deacetylase; Histone deacetylase inhibitor
Core Tip	Histone deacetylases (HDACs) are epigenetic regulators that play an essential role in organ develop-ment and tissue homeostasis. Aberrant HDAC activity contributes to the development of several diseases, including acute and chronic pancreatitis as well as pancreatic cancer. In acute and chronic pancreatitis the inhibition of HDACs exerts significant positive effects of cytokine- and nuclear factor-κB transmitted inflam-mation and tissue damage paralleled by reduced oxidative stress. HDACs are expressed in pancreatic cancer and were functionally linked to key processes of tumor progression (epithelial-mesenchymal-transition, the ubiquitin-proteasome pathway and angiogenesis), indicating a pleiotropic effect of HDACs in pancreatic cancerogenesis. Treatment of pancreatic cancer cells in vitro with HDAC inhibitors alone and/or in combination with conventional cancer agents resulted in diverse beneficial effects, including inhibition of proliferation and cell cycle as well as apoptosis. Therefore, inhibition of HDACs might be a promising strategy for treatment of pancreatic cancer.
Publish Date	2015-12-14 21:02
Citation	Klieser E, Swierczynski S, Mayr C, Schmidt J, Neureiter D, Kiesslich T, Illig R. Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy. World J Gastrointest Oncol 2015; 7(12): 473-483
URL	http://www.wjgnet.com/1948-5204/full/v7/i12/473.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i12.473

Full Article (PDF)	WJGO-7-473.pdf
Full Article (Word)	WJGO-7-473.doc
Manuscript File	20751-Review.docx
Answering Reviewers	20751-Answering reviewers.pdf
Audio Core Tip	20751-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20751-Conflict-of-interest statement.pdf
Copyright License Agreement	20751-Copyright assignment.pdf
Peer-review Report	20751-Peer-review(s).pdf
Scientific Misconduct Check	20751-Scientific misconduct check.pdf
Scientific Editor Work List	20751-Scientific editor work list.pdf