| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Promising biological therapies for ulcerative colitis: A review of the literature
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina and Haruei Ogino |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hirotada Akiho, MD, PhD, Department of Gastroenterology, Kitakyushu Municipal Medical Center, 2-1-1, Bashaku kokurakita-ku, Kitakyushu-shi, Fukuoka 802-0077, Japan. akiho@med.kyushu-u.ac.jp
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| Key Words |
Ulcerative colitis; Biological therapy; Anti-tumor necrosis factor α agents; Janus kinase inhibitor; Anti-integrin agents |
| Core Tip |
Ulcerative colitis (UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants (e.g., cyclosporine, tacrolimus), and surgery. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab and adalimumab have been used for moderate to severe UC, and are effective in inducing and maintaining remission in UC. Recent studies have indicated that golimumab, tofacitinib, vedolizumab and etrolizumab achieved good clinical remission and response rates in UC. In this review, we provide updated information on various biological agents in the treatment of UC.
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| Publish Date |
2015-11-17 12:17 |
| Citation |
Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H. Promising biological therapies for ulcerative colitis: A review of the literature. World J Gastrointest Pathophysiol 2015; 6(4): 219-227 |
| URL |
http://www.wjgnet.com/2150-5330/full/v6/i4/219.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v6.i4.219 |
