Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	20796
Country	Japan

Received	2015-06-22 13:01
Peer-Review Started	2015-06-22 15:16
First Decision by Editorial Office Director
Return for Revision	2015-08-21 12:24
Revised	2015-09-02 17:25
Publication Fee Transferred
Second Decision by Editor	2015-10-14 17:28
Second Decision by Editor-in-Chief	2015-10-17 05:59
Final Decision by Editorial Office Director	2015-10-28 17:55
Articles in Press	2015-10-28 17:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-05 15:28
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Promising biological therapies for ulcerative colitis: A review of the literature
Manuscript Source	Invited Manuscript
All Author List	Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina and Haruei Ogino
Funding Agency and Grant Number
Corresponding Author	Hirotada Akiho, MD, PhD, Department of Gastroenterology, Kitakyushu Municipal Medical Center, 2-1-1, Bashaku kokurakita-ku, Kitakyushu-shi, Fukuoka 802-0077, Japan. akiho@med.kyushu-u.ac.jp
Key Words	Ulcerative colitis; Biological therapy; Anti-tumor necrosis factor α agents; Janus kinase inhibitor; Anti-integrin agents
Core Tip	Ulcerative colitis (UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants (e.g., cyclosporine, tacrolimus), and surgery. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab and adalimumab have been used for moderate to severe UC, and are effective in inducing and maintaining remission in UC. Recent studies have indicated that golimumab, tofacitinib, vedolizumab and etrolizumab achieved good clinical remission and response rates in UC. In this review, we provide updated information on various biological agents in the treatment of UC.
Publish Date	2015-11-17 12:17
Citation	Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H. Promising biological therapies for ulcerative colitis: A review of the literature. World J Gastrointest Pathophysiol 2015; 6(4): 219-227
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/219.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.219

Full Article (PDF)	WJGP-6-219.pdf
Full Article (Word)	WJGP-6-219.doc
Manuscript File	20796-Review.docx
Answering Reviewers	20796-Answering reviewers.pdf
Audio Core Tip	20796-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20796-Conflict-of-interest statement.pdf
Copyright License Agreement	20796-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20796-Language certificate.pdf
Peer-review Report	20796-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20796-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20796-Scientific misconduct check.pdf
Scientific Editor Work List	20796-Scientific editor work list.pdf