Publication Name	World Journal of Nephrology
Manuscript ID	20804
Country	Italy

Received	2015-06-23 09:00
Peer-Review Started	2015-06-23 17:12
To Make the First Decision	2015-07-28 10:50
Return for Revision	2015-08-04 12:02
Revised	2015-08-08 19:27
Second Decision	2015-08-25 17:35
Accepted by Journal Editor-in-Chief	2015-08-25 21:17
Accepted by Executive Editor-in-Chief	2015-08-31 16:57
Articles in Press	2015-08-31 16:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-02 10:43
Publish the Manuscript Online	2015-09-15 08:59

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Urology & Nephrology
Manuscript Type	Frontier
Article Title	Update on immunoglobulin A nephropathy, Part I: Pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Giuseppina Rosso
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, Medical Doctor, Department of Transplantation and Renal Diseases, Careggi University Hospital, viale Pieraccini 18, 50139 Florence, Italy. maurizio.salvadori1@gmail.com
Key Words	Immunoglobulin A; Immunoglobulin A galactosylation; Genome-wide association studies; Auto antibodies; Complement in renal diseases; Mesangial linked growth factors
Core Tip	For few glomerular diseases a new patho-genetic pathway has been recognized in the recent years as happened for the immunoglobulin A (IgA) nephropathy. Finding in the genetics allowed identifying several loci putative for the disease progression. Spectrometry mass studies and 3 dimension studies have allowed bettering clarifying the molecules involved at glomerular level. Molecular studies of the mesangium allowed identifying new receptors responsible for the IgA immune complexes deposition and for the binding to the mesangial structure. Finally molecular and cellular studies opened new ways to understanding the link and the cross-talk between the glomeruli and the tubulointerstitial structure.
Publish Date	2015-09-15 08:59
Citation	Salvadori M, Rosso G. Update on immunoglobulin A nephropathy, Part I: Pathophysiology. World J Nephrol 2015; 4(4): 455-467
URL	http://www.wjgnet.com/2220-6124/full/v4/i4/455.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i4.455

Full Article (PDF)	WJN-4-455.pdf
Full Article (Word)	WJN-4-455.doc
Manuscript File	20804-Review.docx
Answering Reviewers	20804-Answering reviewers.pdf
Audio Core Tip	20804-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20804-Conflict-of-interest statement.pdf
Copyright License Agreement	20804-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20804-Language certification.pdf
Peer-review Report	20804-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20804-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20804-Scientific misconduct check.pdf
Scientific Editor Work List	20804-Scientific editor work list.pdf