Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	20819
Country	Japan

Received	2015-06-24 10:42
Peer-Review Started	2015-06-26 15:54
To Make the First Decision	2015-07-28 10:50
Return for Revision	2015-08-10 09:45
Revised	2015-08-11 14:31
Second Decision	2015-09-06 19:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-16 19:05
Articles in Press	2015-09-16 19:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 17:44
Publish the Manuscript Online	2015-11-10 12:29

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Acute encephalitis and encephalopathy associated with human parvovirus B19 infection in children
Manuscript Source	Invited Manuscript
All Author List	Toru Watanabe and Hideshi Kawashima
Funding Agency and Grant Number
Corresponding Author	Toru Watanabe, PhD, Department of Pediatrics, Niigata City General Hospital, 463-7 Shumoku, Chuo-ku, Niigata 950-1197, Japan. twata@hosp.niigata.niigata.jp
Key Words	Encephalitis; Neurological manifestation; Human parvovirus B19; Encephalopathy; Pathogenesis; Complication
Core Tip	Reports of acute encephalitis and encephalopathy associated with human parvovirus B19 (B19) infection have recently increased. B19 DNA has been detected in cerebrospinal fluid samples in approximately 4% patients with etiologically undiagnosed encephalitis. Some patients were treated with intravenous immunoglobulins and/or steroids. More than half of the patients with B19 encephalitis and encephalopathy recovered completely, but some patients developed severe neurological sequelae or died. Although the precise pathogenesis underlying the development of B19 encephalitis and encephalopathy is unclear, direct B19 infection or NS1 protein of B19 toxicity in the brain, and immune-mediated brain injuries have been proposed.
Publish Date	2015-11-10 12:29
Citation	Watanabe T, Kawashima H. Acute encephalitis and encepha¬lopathy associated with human parvovirus B19 infection in children. World J Clin Pediatr 2015; 4(4): 126-134
URL	http://www.wjgnet.com/2219-2808/full/v4/i4/126.htm
DOI	http://dx.doi.org/10.5409/wjcp.v4.i4.126

Full Article (PDF)	WJCP-4-126.pdf
Full Article (Word)	WJCP-4-126.doc
Manuscript File	20819-Review.docx
Answering Reviewers	20819-Answering reviewers.pdf
Audio Core Tip	20819-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20819-Conflict-of-interest statement.pdf
Copyright License Agreement	20819-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20819-Language certificate.pdf
Peer-review Report	20819-Peer-review(s).pdf
Scientific Misconduct Check	20819-Scientific misconduct check.pdf
Scientific Editor Work List	20819-Scientific editor work list.pdf