Publication Name	World Journal of Translational Medicine
Manuscript ID	20824
Country	Japan

Received	2015-06-24 10:28
Peer-Review Started	2015-06-29 12:18
To Make the First Decision	2015-07-28 10:50
Return for Revision	2015-08-10 09:56
Revised	2015-08-28 09:39
Second Decision	2015-09-29 17:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 18:06
Articles in Press	2015-10-13 18:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-11 09:51
Publish the Manuscript Online	2015-12-15 17:37

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	New categorization of human vascular endothelial cells by pro- vs anti-proliferative phenotypes
Manuscript Source	Invited Manuscript
All Author List	Miwako Nishio, Masako Nakahara, Chikako Sato, Koichi Saeki, Hidenori Akutsu, Akihiro Umezawa, Kazuyuki Tobe, Kazuki Yasuda, Akira Yuo and Kumiko Saeki
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health, Labour and Welfare of Japan KHD1017 JST and PRESTO
Corresponding Author	Kumiko Saeki, MD, PhD, Division Chief, Department of Disease Control, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp
Key Words	Vascular endothelial cells; Vascular smooth muscle cells; Human induced pluripotent stem cells; Human embryonic stem cells; Regulator of G-protein signaling 5; Oxidative stress
Core Tip	There is a longstanding controversy over the effects of vascular endothelial cells (VECs) on the proliferation of vascular smooth muscle cells (VSMCs). Since the controversy came from lack of systematic studies, we performed an integrated analysis using various human VECs to quantitatively evaluate their effects on VSMC proliferation. Here we report that: (1) human VECs are classified into two groups: “pro-proliferative (type-I) vs “anti-proliferative” (type-II); (2) oxidative stress and ageing induced “type-II to type-I” conversion; and (3) RGS5 is the responsible gene for VEC phenotype determinations. Thus, human VECs are categorized into pro-proliferative RGS5high (type-I) and anti-proliferative RGS5low (type-II) VECs.
Publish Date	2015-12-15 17:37
Citation	Nishio M, Nakahara M, Sato C, Saeki K, Akutsu H, Umezawa A, Tobe K, Yasuda K, Yuo A, Saeki K. New categorization of human vascular endothelial cells by pro- vs anti-proliferative phenotypes. World J Transl Med 2015; 4(3): 88-100
URL	http://www.wjgnet.com/2220-6132/full/v4/i3/88.htm
DOI	http://dx.doi.org/10.5528/wjtm.v4.i3.88

Full Article (PDF)	WJTM-4-88.pdf
Full Article (Word)	WJTM-4-88.doc
Manuscript File	20824-Review.docx
Answering Reviewers	20824-Answering reviewers.pdf
Audio Core Tip	20824-Audio core tip.wma
Clinical Trial Registration Statement	20824-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	20824-Conflict-of-interest statement.pdf
Copyright License Agreement	20824-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	20824-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	20824-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	20824-Language certificate.pdf
Peer-review Report	20824-Peer-review(s).pdf
Scientific Misconduct Check	20824-Scientific misconduct check.pdf
Scientific Editor Work List	20824-Scientific editor work list.pdf