Publication Name	World Journal of Gastroenterology
Manuscript ID	2084
Country	Australia

Received	2013-01-25 09:39
Peer-Review Started	2013-01-25 17:25
To Make the First Decision	2013-03-11 15:03
Return for Revision	2013-03-13 12:38
Revised	2013-04-04 23:31
Second Decision	2013-05-07 17:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-08 09:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-10 17:30
Publish the Manuscript Online	2013-09-26 18:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	In vitro effect of amoxicillin and clarithromycin on the 3’ region of cagA gene in Helicobacter pylori isolates
Manuscript Source	Invited Manuscript
All Author List	Javier Andrés Bustamante-Rengifo, Andrés Januer Matta, Alvaro Pazos and Luis Eduardo Bravo
Funding Agency and Grant Number	Funding Agency Grant Number Administrative Department on Science and Innovation of the Republic of Colombia-COLCIENCIAS RC-1106-408-20549 Administrative Department on Science and Innovation of the Republic of Colombia-COLCIENCIAS RC-1106-493-26237 Jóvenes Investigadores e Innovadores “Virginia Gutiérrez de Pineda Universidad del Valle, Cali, Colombia
Corresponding Author	Javier Andrés Bustamante-Rengifo, MSc, Associate Researcher, Registro Poblacional de Cáncer de Cali, Department of Pathology, School of Medicine, Universidad del Valle, Street 4 B N0. 36-00, Building 116, Floor 4°, 760043 Cali, Colombia. javierandres.bustamante@gmail.com
Key Words	Helicobacter pylori; Antimicrobial susceptibility; cag pathogenicity island; cagA 3’region; Random amplified polymorphic DNA-polymerase chain reaction
Core Tip	This study evaluated the in vitro effect of amoxicillin and clarithromycin on the cag pathogenicity island (cag PAI). It was found that the effect of antibiotic pressure does not induce loss of cag PAI, but it can lead - in most cases - to genetic rearrangements (loss or gain of Glu-Pro-Ile-Tyr-Ala motif) within the 3’ region of cagA gene of the founding bacteria that can affect the level of tyrosine phosphorylation impacting on its cellular effects and lead to divergence of cagA-positive subclones, which as a set could alter the pathogenic process of Helicobacter pylori in cases with treatment failure.
Publish Date	2013-09-26 18:39
Citation	Bustamante-Rengifo JA, Matta AJ, Pazos A, Bravo LE. In vitro effect of amoxicillin and clarithromycin on the 3’ region of cagA gene in Helicobacter pylori isolates. World J Gastroenterol 2013; 19(36): 6044-6054
URL	http://www.wjgnet.com/1007-9327/full/v19/i36/6044.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i36.6044

Full Article (PDF)	WJG-19-6044.pdf
Manuscript File	2084-Review.docx
Answering Reviewers	2084-Answering reviewers.doc
Copyright License Agreement	2084-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Guarantee Ethics Committee of Universidad del Valle .pdf
Non-Native Speakers of English Editing Certificate	2084-Language certificate.pdf
Peer-review Report	2084-Peer review(s).pdf
Scientific Editor Work List	2084-Scientific editor work list.doc