Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	20841
Country	Italy

Received	2015-06-24 09:00
Peer-Review Started	2015-06-24 11:42
First Decision by Editorial Office Director
Return for Revision	2015-08-25 20:10
Revised	2015-09-13 22:59
Publication Fee Transferred
Second Decision by Editor	2015-10-13 08:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-10-27 18:20
Articles in Press	2015-10-27 18:20
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-04 10:24
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Host-microbiome interaction in Crohn’s disease: A familiar or familial issue?
Manuscript Source	Invited Manuscript
All Author List	Andrea Michielan and Renata D’Incà
Funding Agency and Grant Number
Corresponding Author	Andrea Michielan, MD, Department of Surgical, Oncological and Gastroenterological Sciences, Azienda Ospedaliera - Università degli Studi di Padova, Via Giustiniani 2, 35128 Padova, Italy. andreamichielan@virgilio.it
Key Words	Crohn’s disease; Genetics; Environment; Microbiome; Relatives
Core Tip	Family studies support a host-microbiome interaction in the development of Crohn’s disease (CD). Unaffected relatives reveal genetic variants in loci involved in detecting bacteria, a greater sero-reactivity to microbial components, an impaired intestinal permeability, and a greater susceptibility to environ-mental factors. Whether genetic or environmental factors drive these conditions is still under investigation, but CD pathogenesis is very likely multifactorial. A genetic burden may be hypothesized in familial CD, while environmental factors may be predominant in sporadic CD.
Publish Date	2015-11-17 12:17
Citation	Michielan A, D’Incà R. Host-microbiome interaction in Crohn’s disease: A familiar or familial issue? World J Gastrointest Pathophysiol 2015; 6(4): 159-168
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/159.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.159

Full Article (PDF)	WJGP-6-159.pdf
Full Article (Word)	WJGP-6-159.doc
Manuscript File	20841-Review.doc
Answering Reviewers	20841-Answering reviewers.pdf
Audio Core Tip	20841-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20841-Conflict-of-interest statement.pdf
Copyright License Agreement	20841-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20841-Language certificate.pdf
Peer-review Report	20841-Peer-review(s).pdf
Scientific Misconduct Check	20841-Scientific misconduct check.pdf
Scientific Editor Work List	20841-Scientific editor work list.pdf