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11/17/2015 12:17:00 PM | Browse: 981 | Download: 1654
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 20841
Country/Territory Italy
Received
2015-06-24 09:00
Peer-Review Started
2015-06-24 11:42
To Make the First Decision
2015-08-16 17:31
Return for Revision
2015-08-25 20:10
Revised
2015-09-13 22:59
Second Decision
2015-10-13 08:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-10-27 18:20
Articles in Press
2015-10-27 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-04 10:24
Publish the Manuscript Online
2015-11-17 12:17
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Host-microbiome interaction in Crohn’s disease: A familiar or familial issue?
Manuscript Source Invited Manuscript
All Author List Andrea Michielan and Renata D’Incà
Funding Agency and Grant Number
Corresponding Author Andrea Michielan, MD, Department of Surgical, Oncological and Gastroenterological Sciences, Azienda Ospedaliera - Università degli Studi di Padova, Via Giustiniani 2, 35128 Padova, Italy. andreamichielan@virgilio.it
Key Words Crohn’s disease; Genetics; Environment; Microbiome; Relatives
Core Tip Family studies support a host-microbiome interaction in the development of Crohn’s disease (CD). Unaffected relatives reveal genetic variants in loci involved in detecting bacteria, a greater sero-reactivity to microbial components, an impaired intestinal permeability, and a greater susceptibility to environ-mental factors. Whether genetic or environmental factors drive these conditions is still under investigation, but CD pathogenesis is very likely multifactorial. A genetic burden may be hypothesized in familial CD, while environmental factors may be predominant in sporadic CD.
Publish Date 2015-11-17 12:17
Citation Michielan A, D’Incà R. Host-microbiome interaction in Crohn’s disease: A familiar or familial issue? World J Gastrointest Pathophysiol 2015; 6(4): 159-168
URL http://www.wjgnet.com/2150-5330/full/v6/i4/159.htm
DOI http://dx.doi.org/10.4291/wjgp.v6.i4.159
Full Article (PDF) WJGP-6-159.pdf
Full Article (Word) WJGP-6-159.doc
Manuscript File 20841-Review.doc
Answering Reviewers 20841-Answering reviewers.pdf
Audio Core Tip 20841-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20841-Conflict-of-interest statement.pdf
Copyright License Agreement 20841-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 20841-Language certificate.pdf
Peer-review Report 20841-Peer-review(s).pdf
Scientific Misconduct Check 20841-Scientific misconduct check.pdf
Scientific Editor Work List 20841-Scientific editor work list.pdf