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        6/2/2016 6:49:00 PM | Browse: 1086 | Download: 2138
    
    
        
        
    
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                    |  | Received |  | 2015-06-26 08:40 | 
    
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                    |  | Peer-Review Started |  | 2015-06-28 11:38 | 
    
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                    |  | To Make the First Decision |  | 2015-10-08 15:54 | 
    
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                    |  | Return for Revision |  | 2015-10-17 19:14 | 
    
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                    |  | Revised |  | 2015-11-04 23:19 | 
    
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                    |  | Second Decision |  | 2016-03-14 17:56 | 
    
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                    |  | Accepted by Journal Editor-in-Chief |  | 2016-03-15 04:40 | 
    
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                    |  | Accepted by Executive Editor-in-Chief |  | 2016-03-25 14:11 | 
    
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                    |  | Articles in Press |  | 2016-03-25 14:11 | 
    
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                    |  | Publication Fee Transferred |  |  | 
    
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                    |  | Edit the Manuscript by Language Editor |  |  | 
    
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                    |  | Typeset the Manuscript |  | 2016-05-16 19:38 | 
            
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                            |  | Publish the Manuscript Online |  | 2016-06-03 09:36 | 
        
        
            
                | ISSN | 2218-4333 (online) | 
            
                | Open Access | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | 
            
                | Copyright | © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | Website | http://www.wjgnet.com | 
        
    
        | Category | Gastroenterology & Hepatology | 
    
        | Manuscript Type | Basic Study | 
    
        | Article Title | Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging | 
    
        | Manuscript Source | Invited Manuscript | 
    
        | All Author List | Julie Veziant, Johan Gagnière, Elodie Jouberton, Virginie Bonnin, Pierre Sauvanet, Denis Pezet, Nicolas Barnich, Elisabeth Miot-Noirault and Mathilde Bonnet | 
    
        | Funding Agency and Grant Number | 
                        
                            
                                | Funding Agency | Grant Number |  
                                        | Ministère de la Santé and the Faculté de Médecine de Clermont-Ferrand |  |  
                                        | Nuovo Soldati Foundation for Cancer Research |  |  | 
    
        | Corresponding Author | Dr. Mathilde Bonnet, PhD, UMR1071 Inserm/Université d’Auvergne and INRA USC2018, Clermont Université, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France. mathilde.bonnet@udamail.fr | 
    
        | Key Words | Colorectal carcinoma; Escherichia coli; Colibactin; Myeloperoxidase; In vivo optical imaging | 
    
        | Core Tip | Approximately 15% of cancers are related to infectious agents. Colorectal cancer (CRC) is thus a complex association of non-neoplastic and tumoral cells and a large amount of microorganisms. Recent studies reported that pks-positive Escherichia coli (E. coli) strains are more frequently detected in CRC, suggesting their possible role in tumor development. Optical imaging has emerged as a powerful tool in translational cancer research, providing new possibilities for the spatiotemporal monitoring of carcinogenesis in mouse models. It may be particularly helpful in better understanding the in vivo host-pathogen-interactions in tumor development. This is the first study to use optical imaging to explore CRC carcinogenesis and associated pathogenic E. coli. | 
            
                | Publish Date | 2016-06-03 09:36 | 
    
        | Citation | Veziant J, Gagnière J, Jouberton E, Bonnin V, Sauvanet P, Pezet D, Barnich N, Miot-Noirault E, Bonnet M. Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging. World J Clin Oncol 2016; 7(3): 293-301 | 
            
                | URL | http://www.wjgnet.com/2218-4333/full/v7/i3/293.htm | 
            
                | DOI | http://dx.doi.org/10.5306/wjco.v7.i3.293 | 
    
    
        
                
        
     
 
                 
             
         
        
    
        
        
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