Publication Name	World Journal of Clinical Oncology
Manuscript ID	20863
Country	France

Received	2015-06-26 08:40
Peer-Review Started	2015-06-28 11:38
To Make the First Decision	2015-10-08 15:54
Return for Revision	2015-10-17 19:14
Revised	2015-11-04 23:19
Second Decision	2016-03-14 17:56
Accepted by Journal Editor-in-Chief	2016-03-15 04:40
Accepted by Executive Editor-in-Chief	2016-03-25 14:11
Articles in Press	2016-03-25 14:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-16 19:38
Publish the Manuscript Online	2016-06-03 09:36

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging
Manuscript Source	Invited Manuscript
All Author List	Julie Veziant, Johan Gagnière, Elodie Jouberton, Virginie Bonnin, Pierre Sauvanet, Denis Pezet, Nicolas Barnich, Elisabeth Miot-Noirault and Mathilde Bonnet
Funding Agency and Grant Number	Funding Agency Grant Number Ministère de la Santé and the Faculté de Médecine de Clermont-Ferrand Nuovo Soldati Foundation for Cancer Research
Corresponding Author	Dr. Mathilde Bonnet, PhD, UMR1071 Inserm/Université d’Auvergne and INRA USC2018, Clermont Université, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France. mathilde.bonnet@udamail.fr
Key Words	Colorectal carcinoma; Escherichia coli; Colibactin; Myeloperoxidase; In vivo optical imaging
Core Tip	Approximately 15% of cancers are related to infectious agents. Colorectal cancer (CRC) is thus a complex association of non-neoplastic and tumoral cells and a large amount of microorganisms. Recent studies reported that pks-positive Escherichia coli (E. coli) strains are more frequently detected in CRC, suggesting their possible role in tumor development. Optical imaging has emerged as a powerful tool in translational cancer research, providing new possibilities for the spatiotemporal monitoring of carcinogenesis in mouse models. It may be particularly helpful in better understanding the in vivo host-pathogen-interactions in tumor development. This is the first study to use optical imaging to explore CRC carcinogenesis and associated pathogenic E. coli.
Publish Date	2016-06-03 09:36
Citation	Veziant J, Gagnière J, Jouberton E, Bonnin V, Sauvanet P, Pezet D, Barnich N, Miot-Noirault E, Bonnet M. Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging. World J Clin Oncol 2016; 7(3): 293-301
URL	http://www.wjgnet.com/2218-4333/full/v7/i3/293.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i3.293

Full Article (PDF)	WJCO-7-293.pdf
Full Article (Word)	WJCO-7-293.doc
Manuscript File	20863-Review.docx
Answering Reviewers	20863-Answering reviewers.pdf
Audio Core Tip	20863-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20863-Conflict-of-interest statement.pdf
Copyright License Agreement	20863-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	20863-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	20863-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	20863-Language certificate.pdf
Peer-review Report	20863-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20863-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20863-Scientific misconduct check.pdf
Scientific Editor Work List	20863-Scientific editor work list.pdf