Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	20865
Country	Türkiye

Received	2015-06-25 09:21
Peer-Review Started	2015-06-28 11:24
To Make the First Decision	2015-09-17 12:23
Return for Revision	2015-09-18 09:12
Revised	2015-10-01 21:18
Second Decision	2015-11-02 14:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-11 18:14
Articles in Press	2015-11-11 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-11 12:23
Publish the Manuscript Online	2016-01-14 20:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Review
Article Title	Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Gulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener and Unal Egeli
Funding Agency and Grant Number
Corresponding Author	Berrin Tunca, PhD, Department of Medical Biology, Faculty of Medicine, Uludag University, Görükle Kampüsü, 16059 Bursa, Turkey. btunca@uludag.edu.tr
Key Words	Early-onset; Colorectal cancer; Epigenetic mechanism; Genetic mechanism; Clinical outcome
Core Tip	Early-onset colorectal cancer (EOCRC) cases are heterogeneous population that include both hereditary and sporadic forms of the colorectal cancer (CRC). EOCRC cases have some distinguishing clinical and pathological features than elder age CRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. We herein discuss the latest findings about genetic and epigenetic features of EOCRC.
Publish Date	2016-01-14 20:17
Citation	Tezcan G, Tunca B, Ak S, Cecener G, Egeli U. Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer. World J Gastrointest Oncol 2016; 8(1): 83-98
URL	http://www.wjgnet.com/1948-5204/full/v8/i1/83.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i1.83

Full Article (PDF)	WJGO-8-83.pdf
Full Article (Word)	WJGO-8-83.doc
Manuscript File	20865-Review.docx
Answering Reviewers	20865-Answering reviewers.pdf
Audio Core Tip	20865-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20865-Conflict-of-interest statement.pdf
Copyright License Agreement	20865-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20865-Language certificate.pdf
Peer-review Report	20865-Peer-review(s).pdf
Scientific Misconduct Check	20865-Scientific misconduct check.pdf
Scientific Editor Work List	20865-Scientific editor work list.pdf