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11/17/2015 12:17:00 PM | Browse: 437 | Download: 550
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 20904
Country/Territory Canada
Received
2015-06-25 17:26
Peer-Review Started
2015-06-26 12:11
To Make the First Decision
2015-08-16 17:00
Return for Revision
2015-08-22 15:00
Revised
2015-08-28 06:36
Second Decision
2015-09-24 17:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-10-13 17:46
Articles in Press
2015-10-13 17:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-23 17:25
Publish the Manuscript Online
2015-11-17 12:17
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Methodology
Manuscript Type Review
Article Title Gastrointestinal dysbiosis and the use of fecal microbial transplantation in Clostridium difficile infection
Manuscript Source Invited Manuscript
All Author List L Patrick Schenck, Paul L Beck and Justin A MacDonald
Funding Agency and Grant Number
Funding Agency Grant Number
Canadian Institutes of Health Research MOP#98004
Corresponding author Justin A MacDonald, Professor, Gastrointestinal Research Group at the Snyder Institute for Chronic Diseases and Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary AB T2N 4Z6, Canada. jmacdo@ucalgary.ca
Keywords human gut microbiota; antibiotic-associated diarrhea; fecal microbial transplant; bacteriotherapy; dysbiosis
Core Tip Emergent literature demonstrates the critical role of the human microbiota in the susceptibility to Clostridium difficile (C. difficile) infection (CDI). Microbial communities may exert effects on the metabolic composition within the GI tract that influence CDI pathogenesis (e.g., bile salt metabolism). The identification of protective and susceptible human gut microbiomes would enable the development of screening tools to identify at-risk patients. Ultimately, the rational design of probiotic cocktails could assist in attenuating C. difficile transmission in hospital or community settings. Prevention of CDI would lead to decreased morbidity and mortality, as well as reduction of hospitalization time and health care costs associated with treatment.
Publish Date 2015-11-17 12:17
Citation Schenck LP, Beck PL, MacDonald JA. Gastrointestinal dysbiosis and the use of fecal microbial transplantation in Clostridium difficile infection. World J Gastrointest Pathophysiol 2015; 6(4): 169-180
Url http://www.wjgnet.com/2150-5330/full/v6/i4/169.htm
DOI http://dx.doi.org/10.4291/wjgp.v6.i4.169
Full Article (PDF) WJGP-6-169.pdf
Full Article (Word) WJGP-6-169.doc
Manuscript File 20904-Review.docx
Answering Reviewers 20904-Answering reviewers.pdf
Audio Core Tip 20904-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 20904-Conflict-of-interest statement.pdf
Copyright License Agreement 20904-Copyright assignment.pdf
Peer-review Report 20904-Peer-review(s).pdf
Scientific Misconduct Check 20904-Scientific misconduct check.pdf
Scientific Editor Work List 20904-Scientific editor work list.pdf