Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	20904
Country	Canada

Received	2015-06-25 17:26
Peer-Review Started	2015-06-26 12:11
To Make the First Decision	2015-08-16 17:00
Return for Revision	2015-08-22 15:00
Revised	2015-08-28 06:36
Second Decision	2015-09-24 17:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 17:46
Articles in Press	2015-10-13 17:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-23 17:25
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Methodology
Manuscript Type	Review
Article Title	Gastrointestinal dysbiosis and the use of fecal microbial transplantation in Clostridium difficile infection
Manuscript Source	Invited Manuscript
All Author List	L Patrick Schenck, Paul L Beck and Justin A MacDonald
Funding Agency and Grant Number	Funding Agency Grant Number Canadian Institutes of Health Research MOP#98004
Corresponding Author	Justin A MacDonald, Professor, Gastrointestinal Research Group at the Snyder Institute for Chronic Diseases and Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary AB T2N 4Z6, Canada. jmacdo@ucalgary.ca
Key Words	human gut microbiota; antibiotic-associated diarrhea; fecal microbial transplant; bacteriotherapy; dysbiosis
Core Tip	Emergent literature demonstrates the critical role of the human microbiota in the susceptibility to Clostridium difficile (C. difficile) infection (CDI). Microbial communities may exert effects on the metabolic composition within the GI tract that influence CDI pathogenesis (e.g., bile salt metabolism). The identification of protective and susceptible human gut microbiomes would enable the development of screening tools to identify at-risk patients. Ultimately, the rational design of probiotic cocktails could assist in attenuating C. difficile transmission in hospital or community settings. Prevention of CDI would lead to decreased morbidity and mortality, as well as reduction of hospitalization time and health care costs associated with treatment.
Publish Date	2015-11-17 12:17
Citation	Schenck LP, Beck PL, MacDonald JA. Gastrointestinal dysbiosis and the use of fecal microbial transplantation in Clostridium difficile infection. World J Gastrointest Pathophysiol 2015; 6(4): 169-180
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/169.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.169

Full Article (PDF)	WJGP-6-169.pdf
Full Article (Word)	WJGP-6-169.doc
Manuscript File	20904-Review.docx
Answering Reviewers	20904-Answering reviewers.pdf
Audio Core Tip	20904-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20904-Conflict-of-interest statement.pdf
Copyright License Agreement	20904-Copyright assignment.pdf
Peer-review Report	20904-Peer-review(s).pdf
Scientific Misconduct Check	20904-Scientific misconduct check.pdf
Scientific Editor Work List	20904-Scientific editor work list.pdf