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1/21/2016 4:10:00 PM | Browse: 519 | Download: 549
Publication Name World Journal of Gastroenterology
Manuscript ID 20906
Country/Territory Japan
Received
2015-06-26 08:45
Peer-Review Started
2015-06-27 13:45
To Make the First Decision
2015-09-09 17:32
Return for Revision
2015-09-15 16:26
Revised
2015-10-07 19:00
Second Decision
2015-12-22 12:37
Accepted by Journal Editor-in-Chief
2015-12-22 19:53
Accepted by Company Editor-in-Chief
2015-12-30 17:25
Articles in Press
2015-12-30 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-11 17:37
Publish the Manuscript Online
2016-01-21 16:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Gender difference in gastro-esophageal reflux diseases
Manuscript Source Invited Manuscript
All Author List Kiyotaka Asanuma, Katsunori Iijima and Tooru Shimosegawa
Funding Agency and Grant Number
Corresponding author Katsunori Iijima, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aobaku Sendai, Miyagi Prefecture 980-8574, Japan. kiijima@med.tohoku.ac.jp
Keywords gastro-esophageal reflux disease; Barrett’s esophagus; esophageal adenocarcinoma; estrogen; male predominance
Core Tip Gastro-esophageal reflux disease (GERD), Barrett’s esophagus and esophageal adenocarcinoma are epidemiologically recognized to be more prevalent in males due to an unknown mechanism. Our recent animal study revealed that estrogen contributes to the gender difference by inactivating inflammatory cells. Additionally, several studies demonstrated that estrogen confers epithelial resistance against causative refluxate and modifies adipose tissue metabolism in obese people and prevent the onset of GERDs. Consequently, the estrogen-related endocrine milieu in women could retard the progression of chronic inflammation to esophageal carcinogenesis, which is likely responsible for the predominance of GERD in males.
Publish Date 2016-01-21 16:10
Citation Asanuma K, Iijima K, Shimosegawa T. Gender difference in gastro-esophageal reflux diseases. World J Gastroenterol 2016; 22(5): 1800-1810
Url http://www.wjgnet.com/1007-9327/full/v22/i5/1800.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i5.1800
Full Article (PDF) WJG-22-1800.pdf
Full Article (Word) WJG-22-1800.doc
Manuscript File 20906-Review.docx
Answering Reviewers 20906-Answering reviewers.pdf
Audio Core Tip 20906-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20906-Conflict-of-interest statement.pdf
Copyright License Agreement 20906-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 20906-Language certificate.pdf
Peer-review Report 20906-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 20906-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 20906-Scientific misconduct check.pdf
Scientific Editor Work List 20906-Scientific editor work list.pdf