Publication Name	World Journal of Gastroenterology
Manuscript ID	20906
Country	Japan

Received	2015-06-26 08:45
Peer-Review Started	2015-06-27 13:45
To Make the First Decision	2015-09-09 17:32
Return for Revision	2015-09-15 16:26
Revised	2015-10-07 19:00
Second Decision	2015-12-22 12:37
Accepted by Journal Editor-in-Chief	2015-12-22 19:53
Accepted by Executive Editor-in-Chief	2015-12-30 17:25
Articles in Press	2015-12-30 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-11 17:37
Publish the Manuscript Online	2016-01-21 16:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gender difference in gastro-esophageal reflux diseases
Manuscript Source	Invited Manuscript
All Author List	Kiyotaka Asanuma, Katsunori Iijima and Tooru Shimosegawa
Funding Agency and Grant Number
Corresponding Author	Katsunori Iijima, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aobaku Sendai, Miyagi Prefecture 980-8574, Japan. kiijima@med.tohoku.ac.jp
Key Words	gastro-esophageal reflux disease; Barrett’s esophagus; esophageal adenocarcinoma; estrogen; male predominance
Core Tip	Gastro-esophageal reflux disease (GERD), Barrett’s esophagus and esophageal adenocarcinoma are epidemiologically recognized to be more prevalent in males due to an unknown mechanism. Our recent animal study revealed that estrogen contributes to the gender difference by inactivating inflammatory cells. Additionally, several studies demonstrated that estrogen confers epithelial resistance against causative refluxate and modifies adipose tissue metabolism in obese people and prevent the onset of GERDs. Consequently, the estrogen-related endocrine milieu in women could retard the progression of chronic inflammation to esophageal carcinogenesis, which is likely responsible for the predominance of GERD in males.
Publish Date	2016-01-21 16:10
Citation	Asanuma K, Iijima K, Shimosegawa T. Gender difference in gastro-esophageal reflux diseases. World J Gastroenterol 2016; 22(5): 1800-1810
URL	http://www.wjgnet.com/1007-9327/full/v22/i5/1800.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i5.1800

Full Article (PDF)	WJG-22-1800.pdf
Full Article (Word)	WJG-22-1800.doc
Manuscript File	20906-Review.docx
Answering Reviewers	20906-Answering reviewers.pdf
Audio Core Tip	20906-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20906-Conflict-of-interest statement.pdf
Copyright License Agreement	20906-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20906-Language certificate.pdf
Peer-review Report	20906-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20906-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20906-Scientific misconduct check.pdf
Scientific Editor Work List	20906-Scientific editor work list.pdf