Publication Name	World Journal of Gastroenterology
Manuscript ID	20943
Country	South Korea

Received	2015-06-26 15:00
Peer-Review Started	2015-06-27 15:24
To Make the First Decision	2015-09-11 08:58
Return for Revision	2015-09-15 15:53
Revised	2015-10-15 13:50
Second Decision	2015-11-09 16:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-24 17:21
Articles in Press	2015-11-24 17:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-15 16:32
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Kichang Han, Jin Hyoung Kim, Gi-Young Ko, Dong Il Gwon and Kyu-Bo Sung
Funding Agency and Grant Number
Corresponding Author	Jin Hyoung Kim, MD, Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Poongnap-2dong, Songpa-gu, Seoul 388-1, South Korea. m1fenew@daum.net
Key Words	Hepatocellular carcinoma; Portal vein tumor thrombosis; Sorafenib; Transarterial chemoembolization; Transarterial radioembolization; Hepatic arterial chemo­therapy; Radiotherapy
Core Tip	Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is associated with a grave prognosis if left untreated. Sorafenib is the only treatment modality recommended for treating HCC patients with PVTT according to most international HCC treatment guidelines. However, the survival benefits observed following systemic sorafenib treatment are only marginal. Under these circumstances, the need for better treatment options remains unfulfilled. In this comprehensive review, various treatment options are presented-including transarterial chemoembolization, transarterial radioembolization, hepatic arterial infusion, chemotherapy, and radiotherapy-and their outcomes, along with combination strategies.
Publish Date	2015-12-31 13:27
Citation	Han K, Kim JH, Ko GY, Gwon DI, Sung KB. Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review. World J Gastroenterol 2016; 22(1): 407-416
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/407.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.407

Full Article (PDF)	WJG-22-407.pdf
Full Article (Word)	WJG-22-407.doc
Manuscript File	20943-Review.docx
Answering Reviewers	20943-Answering reviewers.pdf
Audio Core Tip	20943-Audio core tip.mp3
Copyright License Agreement	20943-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20943-Language certificate.pdf
Peer-review Report	20943-Peer-review(s).pdf
Scientific Misconduct Check	20943-Scientific misconduct check.pdf
Scientific Editor Work List	20943-Scientific editor work list.pdf