Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	20950
Country	United Kingdom

Received	2015-06-27 10:20
Peer-Review Started	2015-07-22 17:20
To Make the First Decision	2015-08-16 17:36
Return for Revision	2015-08-26 09:18
Revised	2015-09-22 21:36
Second Decision	2015-11-02 14:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-11 18:01
Articles in Press	2015-11-11 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-18 21:51
Publish the Manuscript Online	2015-12-24 08:55

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Impact of thiopurines and anti-tumour necrosis factor therapy on hospitalisation and long-term surgical outcomes in ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Christopher Alexakis and Richard CG Pollok
Funding Agency and Grant Number
Corresponding Author	Dr. Richard CG Pollok, FRCP, BSc, PhD, DTMH, Consultant Gastroenterologist and Honorary Reader, Department of Gastroenterology, St George’s University and NHS Trust, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom. richard.pollok@nhs.net
Key Words	Immunomodulator; Azathioprine; Anti-tumour necrosis factor; Thiopurine; Ulcerative colitis; Hospitalisation; Surgery; Colectomy; Admission
Core Tip	Longitudinal population data indicates a protective effect of thiopurines on colectomy in ulcerative colitis in the long-term, but there is limited evidence that they reduce hospitalisation. Research on anti-tumour necrosis factor therapy shows a possible short-term protective effect against colectomy, but more data is needed to address any long-term benefits.
Publish Date	2015-12-24 08:55
Citation	Alexakis C, Pollok RCG. Impact of thiopurines and anti-tumour necrosis factor therapy on hospitalisation and long-term surgical outcomes in ulcerative colitis. World J Gastrointest Surg 2015; 7(12): 360-369
URL	http://www.wjgnet.com/1948-9366/full/v7/i12/360.htm
DOI	http://dx.doi.org/10.4240/wjgs.v7.i12.360

Full Article (PDF)	WJGS-7-360.pdf
Full Article (Word)	WJGS-7-360.doc
Manuscript File	20950-Review.docx
Answering Reviewers	20950-Answering reviewers.pdf
Audio Core Tip	20950-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20950-Conflict-of-interest statement.pdf
Copyright License Agreement	20950-Copyright assignment.pdf
Peer-review Report	20950-Peer-review(s).pdf
Scientific Misconduct Check	20950-Scientific misconduct check.pdf
Scientific Editor Work List	20950-Scientific editor work list.pdf