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Articles Published Processes
2/25/2016 7:30:00 PM | Browse: 1417 | Download: 2193
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Received |
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2015-06-27 10:09 |
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Peer-Review Started |
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2015-07-16 17:32 |
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To Make the First Decision |
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2015-09-17 12:24 |
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Return for Revision |
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2015-09-18 09:18 |
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Revised |
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2015-10-30 19:32 |
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Second Decision |
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2015-11-23 17:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-04 16:14 |
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Articles in Press |
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2015-12-04 16:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-02-20 22:11 |
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Publish the Manuscript Online |
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2016-02-25 19:30 |
| ISSN |
1949-8454 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mai Fujimoto, Yasunobu Mano, Motonobu Anai, Shogo Yamamoto, Masaki Fukuyo, Hiroyuki Aburatani and Atsushi Kaneda |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The CREST program, Japan Agency for Medical Research and Development to Kaneda A |
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| Uehara Memorial Foundation, Takeda Science Foundation |
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| Public Trust Surgery Research Fund to Kaneda A |
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| Corresponding Author |
Atsushi Kaneda, MD, PhD, Professor, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan. kaneda@chiba-u.jp
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| Key Words |
Senescence; Epigenome; Raf; H3K27me3; Histone; Ras |
| Core Tip |
By examining gene expressions and active and repressive histone marks on genome-wide scale, many genes were found to show common expression changes during Ras- and Raf-induced senescence, including genes related to secreted factors and cell cycle. Upregulation of Bmp2 and downregulation of Smad6 were detected and played a role in Raf-induced senes-cence as well as in Ras-induced senescence. Epigenetic alterations to regulate gene expression were also similar, including gain and loss of active histone mark H3K4me3 and loss of H3K27me3. But epigenetic changes are different in part, e.g., in gain of H3K27me3 in Smad6 promoter region.
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| Publish Date |
2016-02-25 19:30 |
| Citation |
Fujimoto M, Mano Y, Anai M, Yamamoto S, Fukuyo M, Aburatani H, Kaneda A. Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence. World J Biol Chem 2016; 7(1): 188-205 |
| URL |
http://www.wjgnet.com/1949-8454/full/v7/i1/188.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v7.i1.188 |
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