Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	21008
Country	Spain

Received	2015-06-29 08:45
Peer-Review Started	2015-07-01 09:04
To Make the First Decision	2015-09-14 17:40
Return for Revision	2015-09-15 14:32
Revised	2015-09-28 07:03
Second Decision	2015-10-14 17:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-27 17:38
Articles in Press	2015-10-27 17:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-03 19:31
Publish the Manuscript Online	2015-12-14 21:02

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Multiple primary colorectal cancer: Individual or familial predisposition?
Manuscript Source	Invited Manuscript
All Author List	José A Pajares and José Perea
Funding Agency and Grant Number	Funding Agency Grant Number Mutua Madrileña Foundation 2012-0036
Corresponding Author	José Perea, MD, PhD, Department of Surgery, 12 de Octubre University Hospital, C/Rosas de Aravaca, 82A. 1º Dcha, E-28023, 28041 Madrid, Spain. josepereag@hotmail.com
Key Words	Multiple primary colorectal cancer; Synchro­nous colorectal cancer; Metachronous colorectal cancer; Chromosomal instability; Microsatellite instabillity; CpG island methylator phenotype
Core Tip	Multiple primary colorectal cancer (MCRC), both Synchronous and Metachronous tumours, is not deeply studied yet, and also has a great clinical impact. Both genetic and environmental factors may affect in the development of MCRC, collaborating in promoting different foci of dysplasia. In general terms, Metachronous forms are mainly related to family factors whereas Synchronous tumours are linked with individual factors. With the exception of cases of hereditary forms of colorectal carcinoma (CRC), the others appears without a well-known molecular basis, and maybe different from sporadic colorectal cancer. For all these reasons, we present a review focused on the state of the art of these particular forms of CRC.
Publish Date	2015-12-14 21:02
Citation	Pajares JA, Perea J. Multiple primary colorectal cancer: Individual or familial predisposition? World J Gastrointest Oncol 2015; 7(12): 434-444
URL	http://www.wjgnet.com/1948-5204/full/v7/i12/434.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i12.434

Full Article (PDF)	WJGO-7-434.pdf
Full Article (Word)	WJGO-7-434.doc
Manuscript File	21008-Review.docx
Answering Reviewers	21008-Answering reviewers.pdf
Audio Core Tip	21008-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21008-Conflict-of-interest statement.pdf
Copyright License Agreement	21008-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21008-Language certificate.pdf
Peer-review Report	21008-Peer-review(s).pdf
Scientific Misconduct Check	21008-Scientific misconduct check.pdf
Scientific Editor Work List	21008-Scientific editor work list.pdf