Publication Name	World Journal of Gastroenterology
Manuscript ID	2102
Country	Japan

Received	2013-01-28 08:40
Peer-Review Started	2013-01-28 17:35
To Make the First Decision	2013-03-04 13:39
Return for Revision	2013-03-08 11:55
Revised
Second Decision	2013-04-18 16:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-19 05:54
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-06-08 01:29
Typeset the Manuscript	2013-06-27 10:24
Publish the Manuscript Online	2013-07-06 17:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men
Manuscript Source	Invited Manuscript
All Author List	Tadamichi Hamachi, Osamu Tajima, Kousaku Uezono, Shinji Tabata, Hiroshi Abe, Keizo Ohnaka and Suminori Kono
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Support Programs for Cancer Research, Grant-in-Aid for Scientific Research on Innovative Areas 221S0001 Ministry of Education, Culture, Sports, Science and Technology, Japan
Corresponding Author	Dr. Suminori Kono, Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. skono@phealth.med.kyushu-u.ac.jp
Key Words	Colorectal adenoma; Smoking; Polymorphism; CYP1A1; GSTM1; GSTT1; NQO1
Core Tip	The study investigated the associations of CYP1A1*2A, CYP1A1*2C, GSTM1, GSTT1 and NQO1 C609T polymorphisms with colorectal adenomas among 455 cases of colorectal adenomas and 1052 controls with no polyps. None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1. A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1. Combination of the CYP1A1*2C and NQO1 609CC genotypes was associated with a decreased risk of colorectal adenomas regardless of smoking status.
Publish Date	2013-07-06 17:46
Citation	Hamachi T, Tajima O, Uezono K, Tabata S, Abe H, Ohnaka K, Kono S. CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men. World J Gastroenterol 2013; 19(25): 4023-4030
URL	http://www.wjgnet.com/1007-9327/full/v19/i25/4023.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i25.4023

Full Article (PDF)	WJG-19-4023.pdf
Manuscript File	2102-Review.doc
Answering Reviewers	2102-Answering reviewers.pdf
Copyright License Agreement	2102-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2102-Language certificate.pdf
Peer-review Report	2102-Peer reviews.pdf
Scientific Editor Work List	2102-Scientific editor work list.doc