Publication Name	World Journal of Hepatology
Manuscript ID	21033
Country	Portugal

Received	2015-06-29 10:09
Peer-Review Started	2015-07-11 10:44
First Decision by Editorial Office Director
Return for Revision	2015-08-20 10:13
Revised
Publication Fee Transferred
Second Decision by Editor	2015-11-30 12:26
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-12-08 15:38
Articles in Press	2015-12-08 15:38
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-07 15:02
Publish the Manuscript Online	2016-01-21 09:23

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis?
Manuscript Source	Invited Manuscript
All Author List	Jorge André Gomes Lopes, Marta Borges-Canha and Pedro Pimentel-Nunes
Funding Agency and Grant Number
Corresponding Author	Pedro Pimentel-Nunes, Professor, Department of Physiology and Cardiothoracic Surgery, Cardio­vascular Research and Development Unit, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. pedronunesml@gmail.com
Key Words	Hepatocarcinoma; Carcinogenesis; Toll-like receptor; Innate immunity; Chronic inflammation
Core Tip	The importance of hepatocarcinoma (HCC) is undeniable in the current medical perspective. However, a lot still remains to be understood in this context. Therefore, this review aims to present the significance of innate immunity in HCC through toll-like receptors as they have already shown interesting effects on tumour’s microenvironment, influencing its progression or regre-ssion. As a result we also render some therapeutic usages of the established knowledge in this area.
Publish Date	2016-01-21 09:23
Citation	Lopes JAG, Borges-Canha M, Pimentel-Nunes P. Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis? World J Hepatol 2016; 8(3): 162-182
URL	http://www.wjgnet.com/1948-5182/full/v8/i3/162.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i3.162

Full Article (PDF)	WJH-8-162.pdf
Full Article (Word)	WJH-8-162.doc
Manuscript File	21033-Review.docx
Answering Reviewers	21033-Answering reviewers.pdf
Audio Core Tip	21033-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21033-Conflict-of-interest statement.pdf
Copyright License Agreement	21033-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21033-Language certificate.pdf
Supplementary Material	Supplementary_Material_20150628075435.docx
Peer-review Report	21033-Peer-review(s).pdf
Scientific Misconduct Check	21033-Scientific misconduct check.pdf
Scientific Editor Work List	21033-Scientific editor work list.pdf