Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	21045
Country	Denmark

Received	2015-06-28 18:22
Peer-Review Started	2015-07-05 16:19
To Make the First Decision	2015-09-17 13:29
Return for Revision	2015-10-08 11:01
Revised	2015-11-14 14:34
Second Decision	2016-01-14 17:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-09 12:30
Articles in Press	2016-03-09 12:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-09 11:51
Publish the Manuscript Online	2016-05-17 12:43

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Systematic Reviews
Article Title	Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Malene Nerstrøm, Peter-Martin Krarup, Lars Nannestad Jorgensen and Magnus S Ågren
Funding Agency and Grant Number
Corresponding Author	Magnus S Ågren, Professor, Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. magnus.agren@mail.dk
Key Words	Anastomotic healing; Colorectal surgery; Breaking strength; Bursting pressure; Anastomotic leakage; Ischemia; Chemotherapy; Reperfusion; Bowel obstruction; Peritonitis; Radiotherapy
Core Tip	Anastomotic leakage is a challenging compli-cation after colorectal surgery. Although many pharma-ceutical compounds have the potential to improve anastomotic healing, none has reached the clinical setting. This study reviewed 65 experimental studies investigating 48 different therapeutic agents for the improvement of anastomotic healing under complicated conditions due to ischemia, ischemia/reperfusion, obstructive bowel, obstructive jaundice, peritonitis, che-motherapy or radiotherapy. Of the 31 agents reported to enhance anastomotic healing, one was subjected to a meta-analysis. Hyperbaric oxygen therapy significantly improved anastomotic healing in rat models complicated by bowel ischemia. Further exploration is needed to define agents that reduce AL in high-risk patients.
Publish Date	2016-05-17 12:43
Citation	Nerstrøm M, Krarup PM, Jorgensen LN, Ågren MS. Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review. World J Gastrointest Surg 2016; 8(5): 389-401
URL	http://www.wjgnet.com/1948-9366/full/v8/i5/389.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i5.389

Full Article (PDF)	WJGS-8-389.pdf
Full Article (Word)	WJGS-8-389.doc
Manuscript File	21045-Review.docx
Answering Reviewers	21045-Answering reviewers.pdf
Audio Core Tip	21045-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21045-Conflict-of-interest statement.pdf
Copyright License Agreement	21045-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21045-Language certificate.pdf
Peer-review Report	21045-Peer-review(s).pdf
Scientific Misconduct Check	21045-Scientific misconduct check.pdf
Scientific Editor Work List	21045-Scientific editor work list.pdf