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Publication Name World Journal of Diabetes
Manuscript ID 21046
Country of Manuscript Source Australia
Received
2015-06-28 18:24
Peer-Review Started
2015-07-14 12:08
To Make the First Decision
2015-09-17 13:29
Return for Revision
2015-10-08 11:35
Revised
Second Decision
2016-02-22 11:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-03-18 16:05
Articles in Press
2016-03-18 16:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-05-03 10:10
Publish the Manuscript Online
2016-05-16 08:52
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Endocrinology and Metabolism
Manuscript Type Review
Article Title Insulin-secreting β cells require a post-genomic concept
Manuscript Source Invited Manuscript
All Author List Fang-Xu Jiang and Grant Morahan
Funding Agency and Grant Number
Funding Agency Grant Number
Juvenile Diabetes Research Foundation 4-2006-1025
Medical Research Foundation of Royal Perth Hospital
Perth Children’s Hospital Research Fund (TPCHRF2013) Grant (to F.X. Jiang) (partly)
Corresponding author Dr. Fang-Xu Jiang, Islet Cell Development Program, Harry Perkins Institute of Medical Research, 6 Verdun St, Nedlands, WA 6009, Australia. fang-xu.jiang@perkins.uwa.edu.au
Keywords Beta cells; Insulin; Post-genome; Concept
Core Tip Pancreatic β cells are highly effective and efficient in the production of insulin, and specialized in its regulated secretion. Deficiency of β cells causes diabetes mellitus, the prevalence of which keeps climbing, despite new drugs continuously becoming available to clinics. Thus regenerative therapies to this devastating disease show great promise. Nevertheless, the generation of β cells requires multiple forced fate changes from pluripotent stem cells and the latter derived insulin+ cells expressing selective key β-cell transcription factors may not be the genuine islet counterparts. Hence their post-genomic concept may help the future development of diabetes regenerative therapies.
Publish Date 2016-05-16 08:52
Citation Jiang FX, Morahan G. Insulin-secreting  cells require a post-genomic concept. World J Diabetes 2016; 7(10): 198-208
Url http://www.wjgnet.com/1948-9358/full/v7/i10/198.htm
DOI http://dx.doi.org/10.4239/wjd.v7.i10.198
Full Article (PDF) WJD-7-198.pdf
Full Article (Word) WJD-7-198.doc
Manuscript File 21046-Review.docx
Answering Reviewers 21046-Answering reviewers.pdf
Audio Core Tip 21046-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21046-Conflict-of-interest statement.pdf
Copyright License Agreement 21046-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 21046-Grant application form(s).pdf
Peer-review Report 21046-Peer-review(s).pdf
Scientific Misconduct Check 21046-Scientific misconduct check.pdf
Scientific Editor Work List 21046-Scientific editor work list.pdf