Publication Name	World Journal of Diabetes
Manuscript ID	21046
Country	Australia

Received	2015-06-28 18:24
Peer-Review Started	2015-07-14 12:08
To Make the First Decision	2015-09-17 13:29
Return for Revision	2015-10-08 11:35
Revised
Second Decision	2016-02-22 11:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-18 16:05
Articles in Press	2016-03-18 16:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-03 10:10
Publish the Manuscript Online	2016-05-16 08:52

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Insulin-secreting β cells require a post-genomic concept
Manuscript Source	Invited Manuscript
All Author List	Fang-Xu Jiang and Grant Morahan
Funding Agency and Grant Number	Funding Agency Grant Number Juvenile Diabetes Research Foundation 4-2006-1025 Medical Research Foundation of Royal Perth Hospital Perth Children’s Hospital Research Fund (TPCHRF2013) Grant (to F.X. Jiang) (partly)
Corresponding Author	Dr. Fang-Xu Jiang, Islet Cell Development Program, Harry Perkins Institute of Medical Research, 6 Verdun St, Nedlands, WA 6009, Australia. fang-xu.jiang@perkins.uwa.edu.au
Key Words	Beta cells; Insulin; Post-genome; Concept
Core Tip	Pancreatic β cells are highly effective and efficient in the production of insulin, and specialized in its regulated secretion. Deficiency of β cells causes diabetes mellitus, the prevalence of which keeps climbing, despite new drugs continuously becoming available to clinics. Thus regenerative therapies to this devastating disease show great promise. Nevertheless, the generation of β cells requires multiple forced fate changes from pluripotent stem cells and the latter derived insulin+ cells expressing selective key β-cell transcription factors may not be the genuine islet counterparts. Hence their post-genomic concept may help the future development of diabetes regenerative therapies.
Publish Date	2016-05-16 08:52
Citation	Jiang FX, Morahan G. Insulin-secreting  cells require a post-genomic concept. World J Diabetes 2016; 7(10): 198-208
URL	http://www.wjgnet.com/1948-9358/full/v7/i10/198.htm
DOI	http://dx.doi.org/10.4239/wjd.v7.i10.198

Full Article (PDF)	WJD-7-198.pdf
Full Article (Word)	WJD-7-198.doc
Manuscript File	21046-Review.docx
Answering Reviewers	21046-Answering reviewers.pdf
Audio Core Tip	21046-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21046-Conflict-of-interest statement.pdf
Copyright License Agreement	21046-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	21046-Grant application form(s).pdf
Peer-review Report	21046-Peer-review(s).pdf
Scientific Misconduct Check	21046-Scientific misconduct check.pdf
Scientific Editor Work List	21046-Scientific editor work list.pdf