Publication Name	World Journal of Immunology
Manuscript ID	21054
Country	Italy

Received	2015-06-29 16:07
Peer-Review Started	2015-07-05 12:05
To Make the First Decision	2015-09-17 13:30
Return for Revision	2015-10-08 12:18
Revised	2015-10-29 17:51
Second Decision	2016-03-28 08:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-04-11 11:41
Articles in Press	2016-04-11 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-18 10:27
Publish the Manuscript Online	2016-07-20 15:35

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Review
Article Title	New insights on chitinases immunologic activities
Manuscript Source	Invited Manuscript
All Author List	Michelino Di Rosa, Violetta Maria Brundo and Lucia Malaguarnera
Funding Agency and Grant Number
Corresponding Author	Lucia Malaguarnera, MD, PhD, Professor, Department of Biomedical and Biotechnology Sciences, University of Catania, 95124 Catania, Italy. lucmal@unict.it
Key Words	Chitinases; Chitinase like proteins; Chronic inflammation; Immune regulation; Autoimmunity
Core Tip	The chitinases and chitinase-like proteins are expressed in response to different pro-inflammatory signals by activated macrophages and in different monocyte-derived cell lines. The mechanism and mole-cular interaction of chitinases in the immune regulation embrace bacterial infection, inflammation, dismetabolic and degenerative disease. The concept of the chitinases involvement in human diseases discussed herein may stimulate the development of new studies leading to a deeper understanding on the biochemical mechanisms inducing chitinases regulation and on the consequences that the increases in chitinases levels impact with immunity and autoimmunity in different conditions. The future understanding on chitinase fun-ctions will lead to the opportunity to develop selective and specific chitinase inhibitors.
Publish Date	2016-07-20 15:35
Citation	Di Rosa M, Brundo VM, Malaguarnera L. New insights on chitinases immunologic activities. World J Immunol 2016; 6(2): 96-104
URL	http://www.wjgnet.com/2219-2824/full/v6/i2/96.htm
DOI	http://dx.doi.org/10.5411/wji.v6.i2.96

Full Article (PDF)	WJI-6-96.pdf
Full Article (Word)	WJI-6-96.doc
Manuscript File	21054-Review.docx
Answering Reviewers	21054-Answering reviewers.pdf
Audio Core Tip	21054-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21054-Conflict-of-interest statement.pdf
Copyright License Agreement	21054-Copyright assignment.pdf
Peer-review Report	21054-Peer-review(s).pdf
Scientific Misconduct Check	21054-Scientific misconduct check.pdf
Scientific Editor Work List	21054-Scientific editor work list.pdf