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Articles Published Processes
2/25/2016 7:04:00 PM | Browse: 900 | Download: 2183
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Received |
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2015-06-29 16:11 |
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Peer-Review Started |
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2015-07-01 17:15 |
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To Make the First Decision |
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2015-09-29 12:47 |
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Return for Revision |
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2015-10-09 17:45 |
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Revised |
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2015-10-17 19:38 |
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Second Decision |
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2015-12-22 12:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-30 17:26 |
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Articles in Press |
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2015-12-30 17:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-01-06 23:16 |
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Typeset the Manuscript |
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2016-01-28 11:46 |
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Publish the Manuscript Online |
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2016-02-25 19:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Heng Sui, Wen-Jing Luo, Qin-Yu Xu and Jing Hua |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81170374 |
| National Natural Science Foundation of China |
81470842(to Hua J) |
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| Corresponding Author |
Jing Hua, MD, PhD, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, No. 160 Pu Jian Road, Shanghai 200127, China. hua-jing88@hotmail.com
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| Key Words |
non-alcoholic fatty liver disease; NOD-like receptor protein 3 inflammasome; saturated fatty acids; polyunsaturated fatty acids; nuclear factor-kappa B |
| Core Tip |
Our research inventively elucidated that high-fat diet-induced hepatic steatosis was sufficient to induce and activate hepatic NOD-like receptor protein 3 (NLRP3) inflammasome, playing an important role in the development of non-alcoholic fatty liver disease. Furthermore, dietary saturated fatty acids and polyunsaturated fatty acids oppositely regulated the activity of NLRP3 inflammasome in hepatocytes and transmitted different sensitization to lipopolysaccharide-induced activation of NLRP3 inflammasome in vitro and in vivo, partly through direct activation or inhibition of nuclear factor-kappa B.
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| Publish Date |
2016-02-25 19:03 |
| Citation |
Sui YH, Luo WJ, Xu QY, Hua J. Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. World J Gastroenterol 2016; 22(8): 2533-2544 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i8/2533.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i8.2533 |
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