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Articles Published Processes
1/31/2016 4:11:00 PM | Browse: 1074 | Download: 1416
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Received |
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2015-06-29 16:37 |
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Peer-Review Started |
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2015-07-05 10:31 |
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To Make the First Decision |
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2015-08-16 17:04 |
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Return for Revision |
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2015-08-24 09:59 |
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Revised |
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2015-09-09 03:23 |
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Second Decision |
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2015-12-11 12:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-18 17:13 |
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Articles in Press |
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2015-12-18 17:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-21 09:50 |
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Publish the Manuscript Online |
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2016-01-31 16:11 |
ISSN |
2150-5330 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Minireviews |
Article Title |
Small bowel neuroendocrine tumors: From pathophysiology to clinical approach
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Manuscript Source |
Invited Manuscript |
All Author List |
Sofia Xavier, Bruno Rosa and José Cotter |
Funding Agency and Grant Number |
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Corresponding Author |
Dr. Sofia Xavier, Department of Gastroenterology, Centro Hospitalar do Alto Ave, Rua dos Cutileiros, Creixomil, 4835-044 Guimarães, Portugal. smaxavier@gmail.com |
Key Words |
Neuroendocrine tumors; Gastrointestinal tumors; Small bowel neoplasms; Carcinoid; Diagnostic markers |
Core Tip |
Annual incidence of neuroendocrine tumors (NETs) has risen in the last years to 40 to 50 cases per million probably due to better diagnostic tools. Recurrent loss of chromosomes 11 and 18 and gains of chromosomes 4, 5, 19 and 20 have been shown in NETs. Several cancer-related pathways were implied in NETs associated mutations, including PI3K/Akt/mTOR and TGF-β pathways. Genes involved in secretory activity were conserved in NETs, however alterations in transcription factors associated with neurodevelopmental process were reported. Studies suggest that miRNA may have a role in ileal NETs development and progression. |
Publish Date |
2016-01-31 16:11 |
Citation |
Xavier S, Rosa B, Cotter J. Small bowel neuroendocrine tumors: From pathophysiology to clinical approach. World J Gastrointest Pathophysiol 2016; 7(1): 117-124 |
URL |
http://www.wjgnet.com/2150-5330/full/v7/i1/117.htm |
DOI |
http://dx.doi.org/10.4291/wjgp.v7.i1.117 |
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