Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	21068
Country	Portugal

Received	2015-06-29 16:37
Peer-Review Started	2015-07-05 10:31
To Make the First Decision	2015-08-16 17:04
Return for Revision	2015-08-24 09:59
Revised	2015-09-09 03:23
Second Decision	2015-12-11 12:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-18 17:13
Articles in Press	2015-12-18 17:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-21 09:50
Publish the Manuscript Online	2016-01-31 16:11

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Small bowel neuroendocrine tumors: From pathophysiology to clinical approach
Manuscript Source	Invited Manuscript
All Author List	Sofia Xavier, Bruno Rosa and José Cotter
Funding Agency and Grant Number
Corresponding Author	Dr. Sofia Xavier, Department of Gastroenterology, Centro Hospitalar do Alto Ave, Rua dos Cutileiros, Creixomil, 4835-044 Guimarães, Portugal. smaxavier@gmail.com
Key Words	Neuroendocrine tumors; Gastrointestinal tumors; Small bowel neoplasms; Carcinoid; Diagnostic markers
Core Tip	Annual incidence of neuroendocrine tumors (NETs) has risen in the last years to 40 to 50 cases per million probably due to better diagnostic tools. Recurrent loss of chromosomes 11 and 18 and gains of chromosomes 4, 5, 19 and 20 have been shown in NETs. Several cancer-related pathways were implied in NETs associated mutations, including PI3K/Akt/mTOR and TGF-β pathways. Genes involved in secretory activity were conserved in NETs, however alterations in transcription factors associated with neurodevelopmental process were reported. Studies suggest that miRNA may have a role in ileal NETs development and progression.
Publish Date	2016-01-31 16:11
Citation	Xavier S, Rosa B, Cotter J. Small bowel neuroendocrine tumors: From pathophysiology to clinical approach. World J Gastrointest Pathophysiol 2016; 7(1): 117-124
URL	http://www.wjgnet.com/2150-5330/full/v7/i1/117.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i1.117

Full Article (PDF)	WJGP-7-117.pdf
Full Article (Word)	WJGP-7-117.doc
Manuscript File	21068-Review.doc
Answering Reviewers	21068-Answering reviewers.pdf
Audio Core Tip	21068-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21068-Conflict-of-interest statement.pdf
Copyright License Agreement	21068-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21068-Language certificate.pdf
Peer-review Report	21068-Peer-review(s).pdf
Scientific Misconduct Check	21068-Scientific misconduct check.pdf
Scientific Editor Work List	21068-Scientific editor work list.pdf