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1/31/2016 4:11:00 PM | Browse: 1074 | Download: 1416
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 21068
Country Portugal
Received
2015-06-29 16:37
Peer-Review Started
2015-07-05 10:31
To Make the First Decision
2015-08-16 17:04
Return for Revision
2015-08-24 09:59
Revised
2015-09-09 03:23
Second Decision
2015-12-11 12:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2015-12-18 17:13
Articles in Press
2015-12-18 17:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-21 09:50
Publish the Manuscript Online
2016-01-31 16:11
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Small bowel neuroendocrine tumors: From pathophysiology to clinical approach
Manuscript Source Invited Manuscript
All Author List Sofia Xavier, Bruno Rosa and José Cotter
Funding Agency and Grant Number
Corresponding Author Dr. Sofia Xavier, Department of Gastroenterology, Centro Hospitalar do Alto Ave, Rua dos Cutileiros, Creixomil, 4835-044 Guimarães, Portugal. smaxavier@gmail.com
Key Words Neuroendocrine tumors; Gastrointestinal tumors; Small bowel neoplasms; Carcinoid; Diagnostic markers
Core Tip Annual incidence of neuroendocrine tumors (NETs) has risen in the last years to 40 to 50 cases per million probably due to better diagnostic tools. Recurrent loss of chromosomes 11 and 18 and gains of chromosomes 4, 5, 19 and 20 have been shown in NETs. Several cancer-related pathways were implied in NETs associated mutations, including PI3K/Akt/mTOR and TGF-β pathways. Genes involved in secretory activity were conserved in NETs, however alterations in transcription factors associated with neurodevelopmental process were reported. Studies suggest that miRNA may have a role in ileal NETs development and progression.
Publish Date 2016-01-31 16:11
Citation Xavier S, Rosa B, Cotter J. Small bowel neuroendocrine tumors: From pathophysiology to clinical approach. World J Gastrointest Pathophysiol 2016; 7(1): 117-124
URL http://www.wjgnet.com/2150-5330/full/v7/i1/117.htm
DOI http://dx.doi.org/10.4291/wjgp.v7.i1.117
Full Article (PDF) WJGP-7-117.pdf
Full Article (Word) WJGP-7-117.doc
Manuscript File 21068-Review.doc
Answering Reviewers 21068-Answering reviewers.pdf
Audio Core Tip 21068-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21068-Conflict-of-interest statement.pdf
Copyright License Agreement 21068-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21068-Language certificate.pdf
Peer-review Report 21068-Peer-review(s).pdf
Scientific Misconduct Check 21068-Scientific misconduct check.pdf
Scientific Editor Work List 21068-Scientific editor work list.pdf