Publication Name	World Journal of Transplantation
Manuscript ID	21147
Country	Brazil

Received	2015-06-29 14:38
Peer-Review Started	2015-07-03 10:36
To Make the First Decision	2015-07-27 15:54
Return for Revision	2015-07-30 17:27
Revised	2015-08-23 01:45
Second Decision	2015-09-14 10:19
Accepted by Journal Editor-in-Chief	2015-09-17 17:54
Accepted by Executive Editor-in-Chief	2015-09-28 17:31
Articles in Press	2015-09-28 17:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-17 10:35
Publish the Manuscript Online	2015-12-23 08:25

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Induced pluripotent stem cells for modeling neurological disorders
Manuscript Source	Invited Manuscript
All Author List	Fabiele B Russo, Fernanda R Cugola, Isabella R Fernandes, Graciela C Pignatari and Patricia C B Beltrão-Braga
Funding Agency and Grant Number
Corresponding Author	Patricia C B Beltrão-Braga, PhD, Assis­tant Professor, Stem Cell Lab, Department of Surgery, School of Veterinary Medicine, University of São Paulo, 87 Prof. Dr. Orlando Marques de Paiva Av., São Paulo 05508-270, Brazil. patriciacbbbraga@usp.br
Key Words	Neurological disorders; Induced pluripotent stem cells; Disease modeling; Human neurons; Drug screening
Core Tip	Several diseases have been successfully modeled using induced pluripotent stem cell (iPSC) technology. Neurological disorders are frequent targets of iPSC-disease modeling for its ability to generate in vitro disease-relevant cell types from the central nervous system, such as neurons and glial cells. Patientspecific iPSC-derived neural cells can recapitulate the phenotypes of these diseases, unveiling mechanisms and providing drug screening platforms for novel therapeutic targets. Here, we review the accomplish-ments and the current progress achieved in human neurological disorders by using iPSC modeling for Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders.
Publish Date	2015-12-23 08:25
Citation	Russo FB, Cugola FR, Fernandes IR, Pignatari GC, Beltrão-Braga PCB. Induced pluripotent stem cells for modeling neurological disorders. World J Transplant 2015; 5(4): 209-221
URL	http://www.wjgnet.com/2220-3230/full/v5/i4/209.htm
DOI	http://dx.doi.org/10.5500/wjt.v5.i4.209

Full Article (PDF)	WJT-5-209.pdf
Full Article (Word)	WJT-5-209.doc
Manuscript File	21147-Review.docx
Answering Reviewers	21147-Answering reviewers.pdf
Audio Core Tip	21147-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21147-Conflict-of-interest statement.pdf
Copyright License Agreement	21147-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21147-Language certificate.pdf
Peer-review Report	21147-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21147-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21147-Scientific misconduct check.pdf
Scientific Editor Work List	21147-Scientific editor work list.pdf