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Articles Published Processes
3/18/2016 2:28:00 PM | Browse: 751 | Download: 1194
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Received |
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2015-06-30 15:39 |
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Peer-Review Started |
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2015-07-04 17:37 |
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To Make the First Decision |
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2015-10-08 16:39 |
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Return for Revision |
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2015-10-16 15:30 |
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Revised |
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2015-11-05 10:15 |
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Second Decision |
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2015-12-17 18:34 |
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Accepted by Journal Editor-in-Chief |
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2015-12-19 22:21 |
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Accepted by Executive Editor-in-Chief |
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2016-01-04 16:45 |
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Articles in Press |
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2016-01-04 16:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-02-19 17:17 |
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Publish the Manuscript Online |
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2016-03-18 14:28 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Adrian D Hibberd, David A Clark, Paul R Trevillian and Patrick Mcelduff |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Kiriwina Investments Limited of Australia |
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| Corresponding Author |
Adrian D Hibberd, MD, FRACS, FACS, Professor of Surgery, Newcastle Transplant Unit, Division of Surgery, John Hunter Hospital, Hunter Region Mail Centre, PO Box 1083, Newcastle, NSW 2310,
Australia. adrian.hibberd@hnehealth.nsw.gov.au
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| Key Words |
Cardiac transplantation; Castanospermine; Cyclosporin A; Positive interaction; Mixed lymphocyte reaction |
| Core Tip |
The authors have established that a biological, castanospermine, interacts with cyclosporin A (CsA) in a synergistic manner when prolonging the survival of cardiac allografts in inbred rats. They suggest that the explanation is not its effect on the mixed lymphocyte reaction nor interference in the metabolism of CsA but rather an inhibition of migration through the basement membrane of the vasculature. They suggest that its effect on heparanase in mononuclear cells and heparan sulphate in the allograft should now be studied. This immunosuppressant holds promise of safe dose reduction of CsA but further assessment of its safety remains.
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| Publish Date |
2016-03-18 14:28 |
| Citation |
Hibberd AD, Clark DA, Trevillian PR, Mcelduff P. Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation. World J Transplant 2016; 6(1): 206-214 |
| URL |
http://www.wjgnet.com/2220-3230/full/v6/i1/206.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v6.i1.206 |
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