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Articles Published Processes
11/12/2015 7:10:00 PM | Browse: 1218 | Download: 2203
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Received |
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2015-06-30 09:22 |
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Peer-Review Started |
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2015-07-05 10:27 |
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To Make the First Decision |
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2015-07-27 15:55 |
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Return for Revision |
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2015-07-31 10:54 |
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Revised |
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2015-08-17 09:43 |
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Second Decision |
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2015-09-21 17:08 |
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Accepted by Journal Editor-in-Chief |
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2015-09-21 22:36 |
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Accepted by Executive Editor-in-Chief |
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2015-09-30 18:24 |
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Articles in Press |
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2015-09-30 18:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-27 11:04 |
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Publish the Manuscript Online |
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2015-11-12 18:51 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Orally administered extract from prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kelley MK Haarberg, Meghan J Wymore Brand, Anne-Marie C Overstreet, Catherine C Hauck, Patricia A Murphy, Jesse M Hostetter, Amanda E Ramer-Tait and Michael J Wannemuehler |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
9P50 AT004155-06 |
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| Corresponding Author |
Dr. Michael J Wannemuehler, Professor, Chair, Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, 2178 Vet Med, Ames, IA 50011, United States. mjwannem@iastate.edu |
| Key Words |
Prunella vulgaris; Spontaneous colitis; Inflammatory bowel disease; Mdr1a; Botanical extract; Mucosal inflammation; Nutraceutical |
| Core Tip |
Extracts of Prunella vulgaris contain multiple anti-inflammatory phenolics and flavonoids and we report that oral administration of an ethanolic extract of P. vulgaris ameliorated the severity of spontaneous colitis in 20 wk old mdr1a-/- mice. Because these mice are genetically prone to develop colitis by 10 wk of age, daily oral treatments were initiated at 6 wk of age. This treatment regimen resulted in the inhibition of multiple parameters of inflammation that collectively contributed to ameliorate the severity of mucosal inflammation suggesting that botanical extracts may be used as effective complementary intervention strategies for the treatment of colitis. |
| Publish Date |
2015-11-12 18:51 |
| Citation |
Haarberg KMK, Wymore Brand MJ, Overstreet AMC, Hauck CC, Murphy PA, Hostetter JM, Ramer-Tait AE, Wannemuehler MJ. Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice. World J Gastrointest Pharmacol Ther 2015; 6(4): 223-237 |
| URL |
http://www.wjgnet.com/2150-5349/full/v6/i4/223.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v6.i4.223 |
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