Publication Name	World Journal of Transplantation
Manuscript ID	21222
Country	Chile

Received	2015-07-02 11:19
Peer-Review Started	2015-07-06 15:34
To Make the First Decision	2015-07-27 15:56
Return for Revision	2015-07-31 16:27
Revised	2015-08-10 06:59
Second Decision	2015-09-06 19:55
Accepted by Journal Editor-in-Chief	2015-09-08 03:06
Accepted by Company Editor-in-Chief	2015-09-18 13:38
Articles in Press	2015-09-18 13:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-15 21:25
Publish the Manuscript Online	2015-12-23 08:25

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Observational Study
Article Title	Combining cytochrome P-450 3A4 modulators and cyclosporine or everolimus in transplantation is successful
Manuscript Source	Invited Manuscript
All Author List	Fernando González and Ricardo Valjalo
Funding Agency and Grant Number
Corresponding Author	Fernando González, MD, MBA, Depart­ment of Nephrology, Faculty of Medicine, Universidad de Chile, Hospital del Salvador, Avenida Salvador 364, Providencia, Santiago 7500922, Chile. fgonzalf@uc.cl
Key Words	Kidney transplant; Immunosuppressive; Cyclosporine; Ketoconazole; Everolimus; Cytochrome P-450; Cytochrome P-450 3A4 modulator
Core Tip	Several immunosuppressive (IS) drugs, used in clinical transplantation, are metabolized by the hepatic cytochrome P-450 system as many other drugs. The co-prescription of IS and ketoconazole reshapes the IS pharmacokinetics and appears to confer benefit to patients receiving calcineurin inhibitors (CNI) and mammalian target of rapamycin inhibitors. We describe the long term follow-up of kidney allograft recipients receiving ketoconazole with a CNI alone or combined with everolimus and report good graft and patient survivals and low rates of acute rejection episodes. These combinations, in low immunological risk kidney transplant recipients are feasible, effective, safe and affordable even in the long term.
Publish Date	2015-12-23 08:25
Citation	González F, Valjalo R. Combining cytochrome P-450 3A4 modulators and cyclosporine or everolimus in transplantation is successful. World J Transplant 2015; 5(4): 338-347
URL	http://www.wjgnet.com/2220-3230/full/v5/i4/338.htm
DOI	http://dx.doi.org/10.5500/wjt.v5.i4.338

Full Article (PDF)	WJT-5-338.pdf
Full Article (Word)	WJT-5-338.doc
Manuscript File	21222-Review.docx
Answering Reviewers	21222-Answering reviewers.pdf
Audio Core Tip	21222-Audio core tip.mp3
Biostatistics Review Certificate	21222-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21222-Conflict-of-interest statement.pdf
Copyright License Agreement	21222-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	21222-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	21222-Language certificate.pdf
Peer-review Report	21222-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21222-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21222-Scientific misconduct check.pdf
Scientific Editor Work List	21222-Scientific editor work list.pdf