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12/10/2015 10:17:00 AM | Browse: 990 | Download: 1533
Publication Name World Journal of Gastroenterology
Manuscript ID 21262
Country/Territory Japan
Received
2015-07-02 16:14
Peer-Review Started
2015-07-06 10:14
To Make the First Decision
2015-07-19 16:36
Return for Revision
2015-08-02 00:17
Revised
2015-08-02 09:31
Second Decision
2015-08-21 13:15
Accepted by Journal Editor-in-Chief
2015-08-21 22:53
Accepted by Company Editor-in-Chief
2015-08-31 18:04
Articles in Press
2015-08-31 18:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-29 15:49
Publish the Manuscript Online
2015-10-19 09:14
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Clinical Trials Study
Article Title Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy
Manuscript Source Unsolicited Manuscript
All Author List Shintaro Tsukinaga, Mikio Kajihara, Kazuki Takakura, Zensho Ito, Tomoya Kanai, Keisuke Saito, Shinichiro Takami, Hiroko Kobayashi, Yoshihiro Matsumoto, Shunichi Odahara, Kan Uchiyama, Hiroshi Arakawa, Masato Okamoto, Haruo Sugiyama, Kazuki Sumiyama, Toshifumi Ohkusa and Shigeo Koido
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Culture, Sports, Science and Technology of Japan
Corresponding Author Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba 277-8567, Japan. shigeo_koido@jikei.ac.jp
Key Words Chemoimmunotherapy; Dendritic cell; Delayed-type hypersensitivity; Interleukin-6; Inter­leukin-8; Pancreatic cancer; Wilms’ tumor 1
Core Tip We recently reported a phase 1 clinical study in pancreatic cancer patients using dendritic cells (DCs) pulsed with multiple major histocompatibility complex class?Ⅰ?and Ⅱ-restricted Wilms’ tumor 1 (WT1) epitopes (DC/WT1-Ⅰ/Ⅱ) in combination with chemotherapy. Little is known about the prognostic markers for the clinical outcomes of chemoimmunotherapy. We exa-mined the association of plasma levels of interleukin (IL)-6/-8 with WT1-specific immune responses and clinical outcomes in pancreatic cancer patients treated with chemotherapy combined with DC/WT1-Ⅰ/Ⅱ. The study demonstrates that prolonged low levels of plasma IL-6/-8 in pancreatic ductal adenocarcinoma patients may be a prognostic marker for the clinical outcomes of chemoimmunotherapy.
Publish Date 2015-10-19 09:14
Citation Tsukinaga S, Kajihara M, Takakura K, Ito Z, Kanai T, Saito K, Takami S, Kobayashi H, Matsumoto Y, Odahara S, Uchiyama K, Arakawa H, Okamoto M, Sugiyama H, Sumiyama K, Ohkusa T, Koido S. Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy. World J Gastroenterol 2015; 21(39): 11168-11178
URL http://www.wjgnet.com/1007-9327/full/v21/i39/11168.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i39.11168
Full Article (PDF) WJG-21-11168.pdf
Full Article (Word) WJG-21-11168.doc
Manuscript File 21262-Review.docx
Answering Reviewers 21262-Answering reviewers.pdf
Audio Core Tip 21262-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21262-Conflict-of-interest statement.pdf
Copyright License Agreement 21262-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21262-Language certificate.pdf
Peer-review Report 21262-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21262-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21262-Scientific misconduct check.pdf
Scientific Editor Work List 21262-Scientific editor work list.pdf