Publication Name	World Journal of Hepatology
Manuscript ID	21278
Country	Italy

Received	2015-07-03 08:33
Peer-Review Started	2015-07-09 16:30
To Make the First Decision	2015-08-16 14:52
Return for Revision	2015-08-25 17:46
Revised	2015-10-15 06:05
Second Decision	2015-11-17 15:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-02 14:23
Articles in Press	2015-12-02 14:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-07 10:50
Publish the Manuscript Online	2015-12-10 15:03

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Massimo Primignani, Giulia Tosetti and Vincenzo La Mura
Funding Agency and Grant Number
Corresponding Author	Massimo Primignani, MD, PhD, U.O. Gastroenterologia ed Epatologia, IRCCS-Ca’ Granda, Ospedale Maggiore Policlinico, via F. Sforza 35, 20122 Milano, Italy. massimo.primignani@policlinico.mi.it
Key Words	Portal vein thrombosis; Coagulopathy; Hypercoagulopathy; Direct acting oral anticoagulant drugs; Cirrhosis
Core Tip	Impaired liver synthesis of both pro- and anticoagulants maintains a haemostatic balance in advanced liver disease, but this balance is more unstable than in healthy subjects and can be easily tipped towards thrombosis or bleeding. Portal vein thrombosis (PVT) frequently occurs in advanced stages of cirrhosis and, if occlusive or extensive, may complicate or impede liver transplant. Therefore, prevention and treatment of PVT are frequent issues in cirrhosis patients, particularly in those eligible to liver transplant. Current treatments are with low molecular weight heparin or vitamin K antagonists and should be continued until transplantation in liver candidates, whereas no consensus exists regard-ing the duration of anticoagulation in non-transplant candidates.
Publish Date	2015-12-10 15:03
Citation	Primignani M, Tosetti G, La Mura V. Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis. World J Hepatol 2015; 7(29): 2906-2912
URL	http://www.wjgnet.com/1948-5182/full/v7/i29/2906.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i29.2906

Full Article (PDF)	WJH-7-2906.pdf
Full Article (Word)	WJH-7-2906.doc
Manuscript File	21278-Review.doc
Answering Reviewers	21278-Answering reviewers.pdf
Audio Core Tip	21278-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21278-Conflict-of-interest statement.pdf
Copyright License Agreement	21278-Copyright assignment.pdf
Peer-review Report	21278-Peer-review(s).pdf
Scientific Misconduct Check	21278-Scientific misconduct check.pdf
Scientific Editor Work List	21278-Scientific editor work list.pdf