Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	21284
Country	United States

Received	2015-07-03 09:14
Peer-Review Started	2015-07-10 09:02
To Make the First Decision	2015-09-28 11:54
Return for Revision	2015-09-30 14:28
Revised	2015-10-09 05:04
Second Decision	2015-11-09 11:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-25 16:09
Articles in Press	2015-11-25 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-10 22:03
Publish the Manuscript Online	2016-01-14 20:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases
Manuscript Source	Invited Manuscript
All Author List	May Cho, Chie Akiba, Cecilia Lau, David Smith, Milhan Telatar, Michelle Afkhami, Stephen Sentovich, Kurt Melstrom and Marwan Fakih
Funding Agency and Grant Number
Corresponding Author	Marwan Fakih, MD, Professor, Department of Medical Oncology, City of Hope National Medical Center, Building 51, Room 101, 1500 E Duarte St., Duarte, CA 91010, United States. mfakih@coh.org
Key Words	RAS; BRAF; Carcinoembryonic antigen; Pattern of metastatic disease; Surveillance
Core Tip	We investigated the impact of RAS and BRAF mutations on pattern of colorectal cancer (CRC) metastases and carcinoembryonic antigen (CEA) production. Patients with RAS mutations were more likely to present with CEA levels < 5 ng/mL. No association was found between RAS and BRAF mutations and sites of metastatic disease at the time of initial diagnosis in our cohort. Our study is the first study to link low CEA production with a RAS mutant status at the time of initial presentation of metastatic CRC. These findings may have clinical implications on surveillance strategies for RAS mutant patients with earlier stages of CRC.
Publish Date	2016-01-14 20:17
Citation	Cho M, Akiba C, Lau C, Smith D, Telatar M, Afkhami M, Sentovich S, Melstrom K, Fakih M. Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases. World J Gastrointest Oncol 2016; 8(1): 128-135
URL	http://www.wjgnet.com/1948-5204/full/v8/i1/128.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i1.128

Full Article (PDF)	WJGO-8-128.pdf
Full Article (Word)	WJGO-8-128.doc
Manuscript File	21284-Review.docx
Answering Reviewers	21284-Answering reviewers.pdf
Audio Core Tip	21284-Audio core tip.m4a
Biostatistics Review Certificate	21284-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21284-Conflict-of-interest statement.pdf
Copyright License Agreement	21284-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20150703085855.docx
Institutional Review Board Approval Form or Document	21284-Institutional review board statement.pdf
Peer-review Report	21284-Peer-review(s).pdf
Scientific Misconduct Check	21284-Scientific misconduct check.pdf
Scientific Editor Work List	21284-Scientific editor work list.pdf