Publication Name	World Journal of Hepatology
Manuscript ID	21285
Country	Japan

Received	2015-07-04 10:38
Peer-Review Started	2015-07-06 17:28
First Decision by Editorial Office Director
Return for Revision	2015-09-08 10:52
Revised	2015-09-20 10:06
Publication Fee Transferred
Second Decision by Editor	2015-11-02 14:23
Second Decision by Editor-in-Chief	2015-11-03 15:41
Final Decision by Editorial Office Director	2015-11-11 18:09
Articles in Press	2015-11-11 18:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-23 12:22
Publish the Manuscript Online	2015-11-27 17:14

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Aiko Fukui, Naoto Kawabe, Senju Hashimoto, Michihito Murao, Takuji Nakano, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Masashi Ohki, Yuka Takagawa, Tomoki Takamura, Hiroyuki Kamei and Kentaro Yoshioka
Funding Agency and Grant Number
Corresponding Author	Kentaro Yoshioka, MD, Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470-1192, Japan. kyoshiok@fujita-hu.ac.jp
Key Words	Vitamin E; Acoustic radiation force impulse; Nonalcoholic fatty liver disease; Velocity of shear wave; Patatin-like phospholipase domain containing 3
Core Tip	Responses to vitamin E treatment in non-alcoholic fatty liver disease patients were assessed by noninvasive scoring systems of hepatic fibrosis, and liver stiffness (velocity of shear wave) was measured by acoustic radiation force impulse elastography. Vitamin E treatment for 1 year improved not only liver enzyme levels but also noninvasive fibrosis scores and liver stiffness. Subsequently, the patients were divided into two groups according to patatin-like phospholipase domain containing 3 (PNPLA3) genotype (CC/CG or GG) to examine whether either group responded differently to the treatment. The responses were similar between different PNPLA3 genotypes.
Publish Date	2015-11-27 17:14
Citation	Fukui A, Kawabe N, Hashimoto S, Murao M, Nakano T, Shimazaki H, Kan T, Nakaoka K, Ohki M, Takagawa Y, Takamura T, Kamei H, Yoshioka K. Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease. World J Hepatol 2015; 7(27): 2749-2756
URL	http://www.wjgnet.com/1948-5182/full/v7/i27/2749.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i27.2749

Full Article (PDF)	WJH-7-2749.pdf
Full Article (Word)	WJH-7-2749.doc