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Articles Published Processes
4/19/2016 9:45:00 AM | Browse: 1103 | Download: 1953
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Received |
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2015-07-04 10:27 |
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Peer-Review Started |
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2015-07-06 13:03 |
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To Make the First Decision |
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2015-08-26 15:10 |
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Return for Revision |
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2015-08-31 17:03 |
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Revised |
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2015-09-24 19:19 |
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Second Decision |
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2015-12-01 10:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-14 15:56 |
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Articles in Press |
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2015-12-14 15:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-02-24 11:44 |
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Typeset the Manuscript |
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2016-03-31 09:36 |
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Publish the Manuscript Online |
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2016-04-19 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Feng Sang, Xiao-Lei Shi, Bing Han, Xu Huang, Tao Huang, Hao-Zhen Ren and Yi-Tao Ding |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81300338 |
| National High-tech R&D Program of China |
2013AA020102 |
| Project funding of Clinical Medical Center of Digestive Disease in Jiangsu Province |
BL2012001 |
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| Corresponding Author |
Dr. Yi-tao Ding, Professor, Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province,
China. yitaoding@hotmail.com
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| Key Words |
Mesenchymal stem cells; Interleukin-1 receptor antagonist; Stem cell transplantation; Acute liver failure; Hepatoectomy |
| Core Tip |
Combination therapy is superior to any method of mesenchymal stem cell (MSC) transplantation used alone. This study shows that combination therapy improved liver function, inhibited apoptosis, and prolonged the survival of swine with acute liver failure (ALF). Transplanted MSCs may participate in liver regeneration by promoting proliferation and inhibiting apoptosis during the initial stage of ALF following antagonism of interleukin-1 inflammatory signaling. Combination therapy with MSC transplantation and an interleukin-1 receptor antagonist, which enables restoration from ALF and liver reconstruction in swine, is a promising treatment option for ALF patients in the future.
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| Publish Date |
2016-04-19 09:42 |
| Citation |
Sang JF, Shi XL, Han B, Huang X, Huang T, Ren HZ, Ding YT. Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy. World J Gastroenterol 2016; 22(16): 4120-4135 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i16/4120.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i16.4120 |
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