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4/19/2016 9:45:00 AM | Browse: 973 | Download: 1475
Publication Name World Journal of Gastroenterology
Manuscript ID 21291
Country/Territory China
Received
2015-07-04 10:27
Peer-Review Started
2015-07-06 13:03
To Make the First Decision
2015-08-26 15:10
Return for Revision
2015-08-31 17:03
Revised
2015-09-24 19:19
Second Decision
2015-12-01 10:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-14 15:56
Articles in Press
2015-12-14 15:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-02-24 11:44
Typeset the Manuscript
2016-03-31 09:36
Publish the Manuscript Online
2016-04-19 09:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy
Manuscript Source Unsolicited Manuscript
All Author List Jian-Feng Sang, Xiao-Lei Shi, Bing Han, Xu Huang, Tao Huang, Hao-Zhen Ren and Yi-Tao Ding
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81300338
National High-tech R&D Program of China 2013AA020102
Project funding of Clinical Medical Center of Digestive Disease in Jiangsu Province BL2012001
Corresponding Author Dr. Yi-tao Ding, Professor, Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. yitaoding@hotmail.com
Key Words Mesenchymal stem cells; Interleukin-1 receptor antagonist; Stem cell transplantation; Acute liver failure; Hepatoectomy
Core Tip Combination therapy is superior to any method of mesenchymal stem cell (MSC) transplantation used alone. This study shows that combination therapy improved liver function, inhibited apoptosis, and prolonged the survival of swine with acute liver failure (ALF). Transplanted MSCs may participate in liver regeneration by promoting proliferation and inhibiting apoptosis during the initial stage of ALF following antagonism of interleukin-1 inflammatory signaling. Combination therapy with MSC transplantation and an interleukin-1 receptor antagonist, which enables restoration from ALF and liver reconstruction in swine, is a promising treatment option for ALF patients in the future.
Publish Date 2016-04-19 09:42
Citation Sang JF, Shi XL, Han B, Huang X, Huang T, Ren HZ, Ding YT. Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy. World J Gastroenterol 2016; 22(16): 4120-4135
URL http://www.wjgnet.com/1007-9327/full/v22/i16/4120.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i16.4120
Full Article (PDF) WJG-22-4120.pdf
Full Article (Word) WJG-22-4120.doc
Manuscript File 21291-Review.doc
Answering Reviewers 21291-Answering reviewers.pdf
Audio Core Tip 21291-Audio core tip.mp3
Biostatistics Review Certificate 21291-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21291-Conflict-of-interest statement.pdf
Copyright License Agreement 21291-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 21291-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 21291-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 21291-Language certificate.pdf
Peer-review Report 21291-Peer-review(s).pdf
Scientific Misconduct Check 21291-Scientific misconduct check.pdf
Scientific Editor Work List 21291-Scientific editor work list.pdf