| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Esophageal testing: What we have so far
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nicola de Bortoli, Irene Martinucci, Lorenzo Bertani, Salvatore Russo, Riccardo Franchi, Manuele Furnari, Salvatore Tolone, Giorgia Bodini, Valeria Bolognesi, Massimo Bellini, Vincenzo Savarino, Santino Marchi and Edoardo Vincenzo Savarino |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Nicola de Bortoli, MD, Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Lungarno Antonio Pacinotti, 43, 54124 Pisa, Italy. nick.debortoli@gmail.com |
| Key Words |
Gastroesophageal reflux disease; High resolution manometry; Multichannel impedance and pH; BRAVO; EndoFLIP; PEP-test; Restech |
| Core Tip |
In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of gastroesophageal reflux disease. High-resolution manometry permits a greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. The Chicago Classification V3.0 could define a hierarchic classification that accurately defines the major and minor disorders of esophageal motility. Esophageal 24-h pH-metry, especially when it is combined with impedance, is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and pH monitoring are able to detect acid and non-acid reflux events. EndoFLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. Recently, up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal pH-metry, have been suggested to detect laryngopharyngeal reflux disease. Future studies are required for these techniques to evaluate their accuracy and usefulness, although the available data are promising. |
| Publish Date |
2016-01-31 16:11 |
| Citation |
de Bortoli N, Martinucci I, Bertani L, Russo S, Franchi R, Furnari M, Tolone S, Bodini G, Bolognesi V, Bellini M, Savarino V, Marchi S, Savarino EV. Esophageal testing: What we have so far. World J Gastrointest Pathophysiol 2016; 7(1): 72-85 |
| URL |
http://www.wjgnet.com/2150-5330/full/v7/i1/72.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v7.i1.72 |
