Publication Name	World Journal of Gastroenterology
Manuscript ID	21308
Country	Taiwan

Received	2015-07-06 08:35
Peer-Review Started	2015-07-07 09:21
To Make the First Decision	2015-07-19 16:37
Return for Revision	2015-07-20 11:27
Revised	2015-08-04 17:45
Second Decision	2015-08-21 13:14
Accepted by Journal Editor-in-Chief	2015-08-23 23:56
Accepted by Executive Editor-in-Chief	2015-09-02 15:31
Articles in Press	2015-09-02 15:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-10 21:19
Typeset the Manuscript	2015-09-16 10:21
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan
Manuscript Source	Unsolicited Manuscript
All Author List	I-Ting Wu, Seng-Kee Chuah, Chen-Hsiang Lee, Chih-Ming Liang, Lung-Sheng Lu, Yuan-Hung Kuo, Yi-Hao Yen, Ming-Luen Hu, Yeh-Pin Chou, Shih-Cheng Yang, Chung-Mou Kuo, Chung-Huang Kuo, Chun-Chih Chien, Yu-Shao Chiang, Shue-Shian Chiou, Tsung-Hui Hu and Wei-Chen Tai
Funding Agency and Grant Number
Corresponding Author	Wei-Chen Tai, MD, Division of Hepatogastroenterology, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan. luketai1019@gmail.com
Key Words	Helicobacter pylori; Antibiotic resistance; Five-year sequential changes; Failed first-line therapy; Southern Taiwan
Core Tip	Antibiotic resistance of Helicobacter pylori (H. pylori) is one of the major causes of eradication therapy failure. This study was designed to assess the 5-year sequential changes in antibiotic resistance of H. pylori in southern Taiwan after the failure of first-line standard triple therapy. The rates of resistance to antibiotics did not show a statistically significant upward or downward trend. Antibiotic resistance of H. pylori has remained a problem in the effective eradication of this type of bacteria in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line therapy for H. pylori eradication. Therefore, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored.
Publish Date	2015-09-28 18:06
Citation	Wu IT, Chuah SK, Lee CH, Liang CM, Lu LS, Kuo YH, Yen YH, Hu ML, Chou YP, Yang SC, Kuo CM, Kuo CH, Chien CC, Chiang YS, Chiou SS, Hu TH, Tai WC. Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan. World J Gastroenterol 2015; 21(37): 10669-10674
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10669.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10669

Full Article (PDF)	WJG-21-10669.pdf
Full Article (Word)	WJG-21-10669.doc
Manuscript File	21308-Review.doc
Answering Reviewers	21308-Answering reviewers.pdf
Audio Core Tip	21308-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21308-Conflict-of-interest statement.pdf
Copyright License Agreement	21308-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150705130451.doc
Institutional Review Board Approval Form or Document	21308-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	21308-Language certificate.pdf
Peer-review Report	21308-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21308-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21308-Scientific misconduct check.pdf
Scientific Editor Work List	21308-Scientific editor work list.pdf