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1/15/2016 9:49:00 AM | Browse: 452 | Download: 566
Publication Name World Journal of Hepatology
Manuscript ID 21335
Country/Territory Israel
Received
2015-07-07 09:11
Peer-Review Started
2015-07-11 17:24
To Make the First Decision
2015-09-16 08:58
Return for Revision
2015-09-22 15:17
Revised
2015-10-02 20:16
Second Decision
2015-12-20 17:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-01-04 17:24
Articles in Press
2016-01-04 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-10 20:01
Publish the Manuscript Online
2016-01-15 09:49
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Hepatitis C and insulin action: An intimate relationship
Manuscript Source Invited Manuscript
All Author List Hilla Knobler and Stephen Malnick
Funding Agency and Grant Number
Corresponding author Hilla Knobler, MD, Diabetes and Metabolic Disease Unit, Kaplan Medical Center, Pasternak St., Rehovot 76100, Israel. knobler@inter.net.il
Keywords Hepatitis C; Type 2 diabetes; Antiviral therapy; Insulin resistance; Insulin signaling
Core Tip Chronic hepatitis C virus (HCV) infection is associated with a higher prevalence of diabetes as compared to either the general population or patients with chronic hepatitis B infections. HCV hepatitis is linked to insulin resistance (IR) early in the disease course, mediated partly by direct inhibitory effect of the viral proteins on insulin signaling. The presence of IR is associated with an increased rate of disease progression to fibrosis, cirrhosis and hepatocellular carcinoma. Interferon and ribavirin treatment of HCV hepatitis may be less successful in the presence of IR. The effect of IR on the new direct-acting antiviral treatment is unclear.
Publish Date 2016-01-15 09:49
Citation Knobler H, Malnick S. Hepatitis C and insulin action: An intimate relationship. World J Hepatol 2016; 8(2): 131-138
Url http://www.wjgnet.com/1948-5182/full/v8/i2/131.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i2.131
Full Article (PDF) WJH-8-131.pdf
Full Article (Word) WJH-8-131.doc
Manuscript File 21335-Review.docx
Answering Reviewers 21335-Answering reviewers.pdf
Audio Core Tip 21335-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 21335-Conflict-of-interest statement.pdf
Copyright License Agreement 21335-Copyright assignment.pdf
Peer-review Report 21335-Peer-review(s).pdf
Scientific Misconduct Check 21335-Scientific misconduct check.pdf
Scientific Editor Work List 21335-Scientific editor work list.pdf