Publication Name	World Journal of Hepatology
Manuscript ID	21335
Country	Israel

Received	2015-07-07 09:11
Peer-Review Started	2015-07-11 17:24
To Make the First Decision	2015-09-16 08:58
Return for Revision	2015-09-22 15:17
Revised	2015-10-02 20:16
Second Decision	2015-12-20 17:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-04 17:24
Articles in Press	2016-01-04 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-10 20:01
Publish the Manuscript Online	2016-01-15 09:49

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatitis C and insulin action: An intimate relationship
Manuscript Source	Invited Manuscript
All Author List	Hilla Knobler and Stephen Malnick
Funding Agency and Grant Number
Corresponding Author	Hilla Knobler, MD, Diabetes and Metabolic Disease Unit, Kaplan Medical Center, Pasternak St., Rehovot 76100, Israel. knobler@inter.net.il
Key Words	Hepatitis C; Type 2 diabetes; Antiviral therapy; Insulin resistance; Insulin signaling
Core Tip	Chronic hepatitis C virus (HCV) infection is associated with a higher prevalence of diabetes as compared to either the general population or patients with chronic hepatitis B infections. HCV hepatitis is linked to insulin resistance (IR) early in the disease course, mediated partly by direct inhibitory effect of the viral proteins on insulin signaling. The presence of IR is associated with an increased rate of disease progression to fibrosis, cirrhosis and hepatocellular carcinoma. Interferon and ribavirin treatment of HCV hepatitis may be less successful in the presence of IR. The effect of IR on the new direct-acting antiviral treatment is unclear.
Publish Date	2016-01-15 09:49
Citation	Knobler H, Malnick S. Hepatitis C and insulin action: An intimate relationship. World J Hepatol 2016; 8(2): 131-138
URL	http://www.wjgnet.com/1948-5182/full/v8/i2/131.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i2.131

Full Article (PDF)	WJH-8-131.pdf
Full Article (Word)	WJH-8-131.doc
Manuscript File	21335-Review.docx
Answering Reviewers	21335-Answering reviewers.pdf
Audio Core Tip	21335-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	21335-Conflict-of-interest statement.pdf
Copyright License Agreement	21335-Copyright assignment.pdf
Peer-review Report	21335-Peer-review(s).pdf
Scientific Misconduct Check	21335-Scientific misconduct check.pdf
Scientific Editor Work List	21335-Scientific editor work list.pdf