Publication Name	World Journal of Gastroenterology
Manuscript ID	21391
Country	United States

Received	2015-07-09 08:36
Peer-Review Started	2015-07-09 15:38
To Make the First Decision	2015-09-29 14:30
Return for Revision	2015-09-30 10:12
Revised	2015-10-25 00:00
Second Decision	2015-12-03 08:06
Accepted by Journal Editor-in-Chief	2015-12-03 15:30
Accepted by Executive Editor-in-Chief	2015-12-14 16:09
Articles in Press	2015-12-14 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-13 09:25
Publish the Manuscript Online	2016-01-21 16:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Clinical and molecular features of young-onset colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Veroushka Ballester, Shahrooz Rashtak and Lisa Boardman
Funding Agency and Grant Number
Corresponding Author	Lisa Boardman, MD, Division of Gastro­enterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. boardman.lisa@mayo.edu
Key Words	Young-onset colorectal cancer; Late-onset colorectal cancer; Microsatellite instability; CpG island methylator phenotype; Chromosomal instability; Microsatellite; Chromosome stable colorectal cancer
Core Tip	Recent evidence supports that young-onset colorectal cancer (CRC) is a “heterogeneous disease”. Newly recognized molecular alterations implicated in tumor progression, appear to contribute to its heterogeneity. Young-onset CRCs are remarkably different compared to late onset CRCs. These differences are highlighted by distinctive histologic features, site of tumor location, stage at presentation, and molecular profile. These differences support the possibility that young-onset CRC may be a different entity than late-onset CRCs. Understanding the molecular mechanisms underlying the development of young-onset CRC, will ultimately help individualize screening strategies and management for this high risk group.
Publish Date	2016-01-21 16:10
Citation	Ballester V, Rashtak S, Boardman L. Clinical and molecular features of young-onset colorectal cancer. World J Gastroenterol 2016; 22(5): 1736-1744
URL	http://www.wjgnet.com/1007-9327/full/v22/i5/1736.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i5.1736

Full Article (PDF)	WJG-22-1736.pdf
Full Article (Word)	WJG-22-1736.doc
Manuscript File	21391-Review.doc
Answering Reviewers	21391-Answering reviewers.pdf
Audio Core Tip	21391-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21391-Conflict-of-interest statement.pdf
Copyright License Agreement	21391-Copyright assignment.pdf
Peer-review Report	21391-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21391-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21391-Scientific misconduct check.pdf
Scientific Editor Work List	21391-Scientific editor work list.pdf