Publication Name	World Journal of Biological Chemistry
Manuscript ID	21403
Country	China

Received	2015-07-09 16:01
Peer-Review Started	2015-07-14 12:25
To Make the First Decision	2015-11-24 14:40
Return for Revision	2015-11-27 08:15
Revised
Second Decision	2015-12-29 11:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-07 16:49
Articles in Press	2016-01-07 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-19 15:14
Publish the Manuscript Online	2016-02-25 19:30

ISSN	1949-8454 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Development of regional specificity of spinal and medullary dorsal horn neurons
Manuscript Source	Invited Manuscript
All Author List	Yu-Feng Xie, Xing-Hong Jiang, Barry J Sessle and Xian-Min Yu
Funding Agency and Grant Number
Corresponding Author	Xian-Min Yu, DSH, Professor, Department of Physiology and Neurobiology, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu Province, China. yuxianminyu1981@hotmail.com
Key Words	Regionalization; Development; Central nervous system; Trigeminal subnucleus caudalis; Spinal cord; Pain
Core Tip	The region-specific control of proliferation, survival and differentiation of neural precursors plays a critical role in development of the central nervous system (CNS). Recent data demonstrated that locally released ninhydrin-reacting small molecules are involved in the region-specific regulation of neuronal development in trigeminal subnuleus caudalis and spinal dorsal horn, which are CNS regions involved in pain signal transmis-sion. These findings not only provide novel insights for understanding CNS regionalization and functional organization, but also raise important questions for future investigations that are needed for the clarification of neuroregenerative processes and for the development of new approaches for treating neurodegenerative diseases and pain.
Publish Date	2016-02-25 19:30
Citation	Xie YF, Jiang XH, Sessle BJ, Yu XM. Development of regional specificity of spinal and medullary dorsal horn neurons. World J Biol Chem 2016; 7(1): 138-145
URL	http://www.wjgnet.com/1949-8454/full/v7/i1/138.htm
DOI	http://dx.doi.org/10.4331/wjbc.v7.i1.138

Full Article (PDF)	WJBC-7-138.pdf
Full Article (Word)	WJBC-7-138.doc
Manuscript File	21403-Review.doc
Answering Reviewers	21403-Answering reviewers.pdf
Audio Core Tip	21403-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21403-Conflict-of-interest_statement.pdf
Copyright License Agreement	21403-Copyright assignment.pdf
Peer-review Report	21403-Peer-review(s).pdf
Scientific Misconduct Check	21403-Scientific misconduct check.pdf
Scientific Editor Work List	21403-Scientific editor work list.pdf