Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	21406
Country	United States

Received	2015-07-10 09:03
Peer-Review Started	2015-07-14 17:15
To Make the First Decision	2015-09-16 09:14
Return for Revision	2015-09-22 18:05
Revised	2015-10-12 10:25
Second Decision	2015-11-02 14:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-11 18:10
Articles in Press	2015-11-11 18:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-19 17:50
Publish the Manuscript Online	2015-12-24 08:55

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Hypoalbuminemia in colorectal cancer prognosis: Nutritional marker or inflammatory surrogate?
Manuscript Source	Invited Manuscript
All Author List	Bassel Nazha, Elias Moussaly, Mazen Zaarour, Chanudi Weerasinghe and Basem Azab
Funding Agency and Grant Number
Corresponding Author	Bassel Nazha, MD, MPH, Resident Physician, Department of Medicine, North Shore-LIJ Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, United States. bnazha@nshs.edu
Key Words	Hypoalbuminemia; Albumin; Colorectal cancer; Albumin-to-globulin ratio; Cancer survival; Systemic inflammatory response; Glasgow prognostic score
Core Tip	Early studies had shown a prognostic value of hypoalbuminemia in colorectal cancer. The relationship between albumin levels and survival was more consistent when the former was coupled to C-reactive protein, a classic inflammatory marker, in the modified Glasgow prognostic score (mGPS). This relationship also appeared to be independent of nutrition on multivariate analyses. The superiority of mGPS in predicting survival supports inflammation as the major culprit of poorer outcomes. A number of studies showing an association of lower albumin-to-globulin ratios with poorer survival are also in favor of a tilt towards proinflammatory states as the cause of morbidity and mortality. Cancer cachexia is a downstream consequence of the systemic inflammation brought in by colorectal cancer. In this view, albumin is a negative acute phase reactant rather than a nutritional marker. Interventions aimed to halt cancer cachexia should therefore target inflammation.
Publish Date	2015-12-24 08:55
Citation	Nazha B, Moussaly E, Zaarour M, Weerasinghe C, Azab B. Hypoalbuminemia in colorectal cancer prognosis: Nutritional marker or inflammatory surrogate? World J Gastrointest Surg 2015; 7(12): 370-377
URL	http://www.wjgnet.com/1948-9366/full/v7/i12/370.htm
DOI	http://dx.doi.org/10.4240/wjgs.v7.i12.370

Full Article (PDF)	WJGS-7-370.pdf
Full Article (Word)	WJGS-7-370.doc
Manuscript File	21406-Review.docx
Answering Reviewers	21406-Answering reviewers.pdf
Audio Core Tip	21406-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21406-Conflict-of-interest statement.pdf
Copyright License Agreement	21406-Copyright assignment.pdf
Peer-review Report	21406-Peer-review(s).pdf
Scientific Misconduct Check	21406-Scientific misconduct check.pdf
Scientific Editor Work List	21406-Scientific editor work list.pdf