| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
HMC Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic and Richard L Whelan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Mr. Wade Thompson and family to the Divisions of Colon and Rectal surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019 |
|
|
| Corresponding Author |
Richard L Whelan, MD, Professor of Surgery, Chief, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, Suite 7B, 425 West, 59th Street, New York, NY 10019, United States. rwhelan@chpnet.org |
| Key Words |
Colorectal cancer; Recurrence; Minimally inasive colorectal resection; Chitinase 3-like 1; Metastasis |
| Core Tip |
Colorectal cancer (CRC) resection surgery is well known to be associated with short lived immunosuppression and transient plasma protein changes. We have documented that a second set of blood protein alterations that last for 3 to 5 wk after CRC; interestingly, all of these proteins play a role in angiogenesis. This group of pro-angiogenic proteins includes vascular endothelial growth factor, placental growth factor, angiopoietin-2, monocyte chemo-attractant protein-1 and matrix metalloproteinase 2. Our published data further confirms that pro-angiogenic postoperative plasma from cancer patients stimulates in vitro endothelial cell proliferation, migration, and invasion. In this manuscript we are presenting data to demonstrate that a pro-angiogenic protein, chitinase 3-like 1, in CRC patients remain elevated for month after minimally invasive colorectal resection. |
| Publish Date |
2016-08-09 08:50 |
| Citation |
Shantha Kumara HMC, Gaita D, Miyagaki H, Yan X, Hearth SAC, Njoh L, Cekic V, Whelan RL. Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection. World J Gastrointest Oncol 2016; 8(8): 607-614 |
| URL |
http://www.wjgnet.com/1948-5204/full/v8/i8/607.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v8.i8.607 |
