Publication Name	World Journal of Diabetes
Manuscript ID	21452
Country	Denmark

Received	2015-07-22 11:06
Peer-Review Started	2015-07-24 14:54
To Make the First Decision	2015-08-14 11:50
Return for Revision	2015-08-25 18:57
Revised	2015-09-14 00:51
Second Decision	2015-10-13 08:47
Accepted by Journal Editor-in-Chief	2015-10-15 01:53
Accepted by Company Editor-in-Chief	2015-10-27 18:23
Articles in Press	2015-10-27 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-13 20:22
Publish the Manuscript Online	2016-01-19 08:33

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Brain changes in diabetes mellitus patients with gastrointestinal symptoms
Manuscript Source	Unsolicited Manuscript
All Author List	Anne M Drewes, Eirik Søfteland, Georg Dimcevski, Adam D Farmer, Christina Brock, Jens B Frøkjær, Klaus Krogh and Asbjørn M Drewes
Funding Agency and Grant Number
Corresponding Author	Asbjørn M Drewes, PhD, DMSc, Professor, Mech-Sense, Department of Gastroenterology and Hepatology and Clinical Institute, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark. amd@rn.dk
Key Words	Diabetes mellitus; Gastrointestinal; Electro­encephalogram; Magnetic resonance imaging; Brain
Core Tip	Investigation of the existing literature on diabetes patients with gastrointestinal (GI) sym-ptoms indicates the presence of structural and fun-ctional brain changes. This was most consistent in electrophysiological studies, where especially changes in the insula seemed to correlate with GI symptoms. Imaging studies confirmed the electrophysiological findings showing microstructural changes in brain areas involved in visceral sensory processing. Due to these findings, future targets in treatment of GI symptoms in patients with diabetes may be based on modulation of central nervous system reorganisation, either pharmacologically or with afferent nerve stimulation.
Publish Date	2016-01-19 08:33
Citation	Drewes AM, Søfteland E, Dimcevski G, Farmer AD, Brock C, Frøkjær JB, Krogh K, Drewes AM. Brain changes in diabetes mellitus patients with gastrointestinal symptoms. World J Diabetes 2016; 7(2): 14-26
URL	http://www.wjgnet.com/1948-9358/full/v7/i2/14.htm
DOI	http://dx.doi.org/10.4239/wjd.v7.i2.14

Full Article (PDF)	WJD-7-14.pdf
Manuscript File	21452-Review.docx
Answering Reviewers	21452-Answering reviewers.pdf
Audio Core Tip	21452-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	21452-Conflict-of-interest statement.pdf
Copyright License Agreement	21452-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150713161329.png
Non-Native Speakers of English Editing Certificate	21452-Language certificate.pdf
Supplementary Material	Supplementary_Material_20150713161543.png
Peer-review Report	21452-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21452-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21452-Scientific misconduct check.pdf
Scientific Editor Work List	21452-Scientific editor work list.pdf