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Publication Name World Journal of Gastroenterology
Manuscript ID 21453
Country/Territory China
Received
2015-07-29 17:40
Peer-Review Started
2015-07-30 18:52
To Make the First Decision
2015-10-15 08:13
Return for Revision
2015-10-18 15:19
Revised
2015-11-04 14:09
Second Decision
2015-12-08 13:53
Accepted by Journal Editor-in-Chief
2015-12-08 17:33
Accepted by Company Editor-in-Chief
2015-12-21 13:57
Articles in Press
2015-12-21 13:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-01-19 03:31
Typeset the Manuscript
2016-02-16 16:57
Publish the Manuscript Online
2016-02-25 19:03
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Role of CD56-expressing immature biliary epithelial cells in biliary atresia
Manuscript Source Unsolicited Manuscript
All Author List Rui-Zhong Zhang, Jia-Kang Yu, Jiao Peng, Feng-Hua Wang, Hai-Ying Liu, Vincent CH Lui, John M Nicholls, Paul KH Tam, Jonathan R Lamb, Yan Chen and Hui-Min Xia
Funding Agency and Grant Number
Funding Agency Grant Number
State Clinical Key Specialty Construction Project (Pediatric Surgery) 2013 GJLCZD1301
Guangdong Provincial Science and Technology Plan Projects 2014 2014A020212373
Corresponding Author Yan Chen, PhD, Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong province, China. ychenc@hku.hk
Key Words Biliary atresia; CD56; epithelial cell adhesion molecule; cytokeratin 7; Biliary epithelial cells; Liver fibrosis
Core Tip Clinical laboratory parameters did not correlate with tissue fibrosis in patients with biliary atresia (BA). Immunohistochemical staining showed that CD56-positive immature bile ducts were present only in patients with BA but not in those with choledochal cyst or neonatal hepatitis. The number of CD56 expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage. Furthermore, the signaling molecule Notch1, but not Notch2, was co-expressed in CD56 positive cells. Our data provide new insights into the pathogenesis of BA in terms of biliary epithelial cell maturation and Notch expression.
Publish Date 2016-02-25 19:03
Citation Zhang RZ, Yu JK, Peng J, Wang FH, Liu HY, Lui VCH, Nicholls JM, Tam PKH, Lamb JR, Chen Y, Xia HM. Role of CD56-expressing immature biliary epithelial cells in biliary atresia. World J Gastroenterol 2016; 22(8): 2545-2557
URL http://www.wjgnet.com/1007-9327/full/v22/i8/2545.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i8.2545
Full Article (PDF) WJG-22-2545.pdf
Full Article (Word) WJG-22-2545.doc
Manuscript File 21453-Review.doc
Answering Reviewers 21453-Answering reviewers.pdf
Audio Core Tip 21453-Audio core tip.mp3
Biostatistics Review Certificate 21453-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21453-Conflict-of-interest statement.pdf
Copyright License Agreement 21453-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 21453-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 21453-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 21453-Language certificate.PDF
Peer-review Report 21453-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21453-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21453-Scientific misconduct check.pdf
Scientific Editor Work List 21453-Scientific editor work list.pdf