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Articles Published Processes
1/31/2016 4:11:00 PM | Browse: 1609 | Download: 2478
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Received |
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2015-07-15 09:27 |
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Peer-Review Started |
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2015-07-17 18:05 |
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To Make the First Decision |
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2015-08-31 16:38 |
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Return for Revision |
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2015-09-02 15:15 |
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Revised |
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Second Decision |
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2015-12-11 12:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-18 17:15 |
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Articles in Press |
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2015-12-18 17:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-23 11:57 |
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Publish the Manuscript Online |
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2016-01-31 16:11 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Efficacy and tolerability of hydrogen carbonate-rich water for heartburn
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
André-Michael Beer, Ralf Uebelhack and Ute Pohl |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Deutsche Heilbrunnen im Verband Deutscher Mineralbrunnen e. V., Germany |
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| Corresponding Author |
Dr. Ute Pohl, Analyze and Realize GmbH, Waldseeweg 6, 13456 Berlin, Germany. upohl@a-r.com |
| Key Words |
Heartburn; Hydrogen carbonate-rich mineral water; Open clinical pilot study; Patients; Regurgitation; Gastroesophageal reflux disease symptoms; Dyspepsia; Blood pressure; Tolerability; Quality of life |
| Core Tip |
This open, single-center, single-arm clinical study investigated the efficacy and safety of mineral water with a high content of hydrogen carbonate in patients with heartburn. After 6 wk, the occurrence of heartburn was statistically significantly reduced both in the intention-to-treat (48 patients) and the per-protocol populations (42 patients). All dimensions of the Reflux Disease Questionnaire (heartburn, regurgitation, gastroesophageal reflux disease symptoms, dyspepsia) showed significant improvement at week 6. Likewise, disease-specific quality of life improved significantly, and there was a slight but significant decrease in blood pressure. The tolerability was rated good or very good by 96% of patients and investigators. |
| Publish Date |
2016-01-31 16:11 |
| Citation |
Beer AM, Uebelhack R, Pohl U. Efficacy and tolerability of hydrogen carbonate-rich water for heartburn. World J Gastrointest Pathophysiol 2016; 7(1): 171-180 |
| URL |
http://www.wjgnet.com/2150-5330/full/v7/i1/171.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v7.i1.171 |
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