Publication Name	World Journal of Gastroenterology
Manuscript ID	21493
Country	Germany

Received	2015-07-15 17:14
Peer-Review Started	2015-07-17 19:08
To Make the First Decision	2015-08-31 08:30
Return for Revision	2015-09-06 11:20
Revised
Second Decision	2016-01-22 14:27
Accepted by Journal Editor-in-Chief	2016-01-22 15:00
Accepted by Executive Editor-in-Chief	2016-01-30 17:18
Articles in Press	2016-01-30 17:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-29 09:27
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Effective treatment of gastrointestinal bleeding with thalidomide - Chances and limitations
Manuscript Source	Invited Manuscript
All Author List	Juergen Bauditz
Funding Agency and Grant Number
Corresponding Author	Dr. Juergen Bauditz, department of Internal Medicine, Helios Klinik Anhalt/Zerbst, Friedrich-Naumann Street 53, 39261 Zerbst, Germany. juergen.bauditz@helios-kliniken.de
Key Words	Thalidomide; Angiodysplasia; Vascular malformation; Gastrointestine; Bleeding; Therapy; Angiogenesis; Vascular endothelial growth factor
Core Tip	Traditionally, bleeding from gastrointestinal angiodysplasias has been treated by hormonal therapy. After a randomized study finally demonstrated that hormones are not efficient, treatment has switched to endoscopic coagulation techniques. Thalidomide was recently proven to be highly effective for treatment of bleeding from gastrointestinal angiodysplasias and is also useful for bleeding in hereditary hemorrhagic telangiectasia. However, thalidomide is rarely used as it is still notorious for its teratogenicity. Patients with gastrointestinal bleeding related to angiodysplasias are generally old and teratogenicity is not an important issue. Other side-effects of thalidomide like neurotoxicity may limit treatment options but can be monitored safely.
Publish Date	2016-03-14 08:44
Citation	Bauditz J. Effective treatment of gastrointestinal bleeding with thalidomide - Chances and limitations. World J Gastroenterol 2016; 22(11): 3158-3164
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3158.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3158

Full Article (PDF)	WJG-22-3158.pdf
Full Article (Word)	WJG-22-3158.doc
Manuscript File	21493-Review.docx
Answering Reviewers	21493-Answering reviewers.pdf
Audio Core Tip	21493-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	21493-Conflict-of-interest statement.pdf
Copyright License Agreement	21493-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21493-Language certificate.pdf
Peer-review Report	21493-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21493-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21493-Scientific misconduct check.pdf
Scientific Editor Work List	21493-Scientific editor work list.pdf