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3/14/2016 8:44:00 AM | Browse: 1117 | Download: 1700
Publication Name World Journal of Gastroenterology
Manuscript ID 21493
Country/Territory Germany
Received
2015-07-15 17:14
Peer-Review Started
2015-07-17 19:08
To Make the First Decision
2015-08-31 08:30
Return for Revision
2015-09-06 11:20
Revised
Second Decision
2016-01-22 14:27
Accepted by Journal Editor-in-Chief
2016-01-22 15:00
Accepted by Company Editor-in-Chief
2016-01-30 17:18
Articles in Press
2016-01-30 17:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-29 09:27
Publish the Manuscript Online
2016-03-14 08:44
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Effective treatment of gastrointestinal bleeding with thalidomide - Chances and limitations
Manuscript Source Invited Manuscript
All Author List Juergen Bauditz
Funding Agency and Grant Number
Corresponding Author Dr. Juergen Bauditz, department of Internal Medicine, Helios Klinik Anhalt/Zerbst, Friedrich-Naumann Street 53, 39261 Zerbst, Germany. juergen.bauditz@helios-kliniken.de
Key Words Thalidomide; Angiodysplasia; Vascular malformation; Gastrointestine; Bleeding; Therapy; Angiogenesis; Vascular endothelial growth factor
Core Tip Traditionally, bleeding from gastrointestinal angiodysplasias has been treated by hormonal therapy. After a randomized study finally demonstrated that hormones are not efficient, treatment has switched to endoscopic coagulation techniques. Thalidomide was recently proven to be highly effective for treatment of bleeding from gastrointestinal angiodysplasias and is also useful for bleeding in hereditary hemorrhagic telangiectasia. However, thalidomide is rarely used as it is still notorious for its teratogenicity. Patients with gastrointestinal bleeding related to angiodysplasias are generally old and teratogenicity is not an important issue. Other side-effects of thalidomide like neurotoxicity may limit treatment options but can be monitored safely.
Publish Date 2016-03-14 08:44
Citation Bauditz J. Effective treatment of gastrointestinal bleeding with thalidomide - Chances and limitations. World J Gastroenterol 2016; 22(11): 3158-3164
URL http://www.wjgnet.com/1007-9327/full/v22/i11/3158.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i11.3158
Full Article (PDF) WJG-22-3158.pdf
Full Article (Word) WJG-22-3158.doc
Manuscript File 21493-Review.docx
Answering Reviewers 21493-Answering reviewers.pdf
Audio Core Tip 21493-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 21493-Conflict-of-interest statement.pdf
Copyright License Agreement 21493-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21493-Language certificate.pdf
Peer-review Report 21493-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21493-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21493-Scientific misconduct check.pdf
Scientific Editor Work List 21493-Scientific editor work list.pdf